Programmed cell death protein 1 (PD-1), (CD279 cluster of differentiation 279). PD-1 is a protein encoded in humans by the PDCD1 gene.

pd-1（程序性死亡受体1），也称为cd279（分化簇279），是一种重要的免疫抑制分子。 通过向下调节免疫系统对人体细胞的反应，以及通过抑制T细胞炎症活动来调节免疫系统并促进自身耐受。

6 天之前 · Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of …

程序性死亡分子 (Programmed death-1, PD-1)又名CD279，是继CTLA4发现之后又一个重要的负性共刺激分子。 它的配体 PD-L1 ，又名CD274，同属CD28/B7超家族。 PD-1与其配体结合后，传导的负性共刺激信号能抑制 T淋巴细胞 增殖，在调节T细胞活化和 免疫耐受 过程中发挥关键 ...

程序性细胞死亡蛋白1，又称PD-1和CD279，是一种细胞表面受体，通过抑制T细胞炎症活性，在下调免疫系统和促进自我耐受方面发挥重要作用。 在人类中，它由 PDCD1基因 编码。 PD-1是免疫球蛋白超家族的一员，在t细胞和前b细胞上表达。 PD-1作为受体，有两个配体PD-L1 (B7-H1)和PD-L2 (B7-DC)。 当PD-1与配体结合时，可诱导淋巴结内抗原特异性t细胞发生凋亡 (程序性细胞死亡)的双重机制，同时减少 调节性t细胞 (抗炎、抑制性t细胞)的凋亡。 根据之前的研究，我们 …

程序性死亡蛋白-1 （PD-1/CD279），是重要的 免疫检查点，主要表达于活化 T细胞 上的一种跨膜蛋白质，同时在 B细胞， NK细胞 和 Treg细胞 中也有表达，与其两个配体 PD-L1 和 PD-L2 的作用而抑制T细胞的活化和细胞因子的产生。 PD-L2亲和力为PD-L1的2-6倍，但PD-L1表达范围更广。 PD-L1为PD-1最重要的天然配体，I型糖蛋白又称CD274或B7-H1，大多数肿瘤细胞通过表达PD-L1实现免疫逃逸。 PD-L2是与PD-1结合的第二个重要配体，也是I型糖蛋白又称CD273或B7 …

Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells. PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also compromises anti-tumor immunity. Blocking antibodies against PD-1 or its ligands have revolutionized cancer immunotherapy.

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells.

CD279 is a cell surface protein predominantly expressed on T cells. Its ligands CD273 and CD274 are expressed on antigen‐presenting cells and tumors. CD279 has been shown to act as an important immune check point by inhibiting CD8 T cell activation, and antibodies against CD279 enhance T cell‐mediated cytotoxic function.

Antibodies that detect PD-1 (CD279) can be used in several scientific applications, including Flow Cytometry, Immunohistochemistry, Western Blot, Immunocytochemistry and ELISA. These antibodies target PD-1 (CD279) in Human, Mouse, Rhesus …