CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.Unlike many of the antibody receptors, CD23 is a C-type lectin.It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

cd23有2种形式：cd23最初作为一种膜结合分子表达，但它可能被adam-10等金属蛋白酶从细胞表面裂解，产生不同分子量的可溶性cd23片段（scd23）。 CD23有2种异构体：CD23a和CD23b，二者的不同之处是前者在细胞内有21个氨基酸，后者为22个。

2024年5月21日 · CD23 antibodies may decrease adherence of Plasmodium falciparum infected erythrocytes (Cell Microbiol 2004;6:839) CD23 levels correlate with Plasmodium falciparum malaria severity (Acta Trop 2016;154:25) CD23 mediates antimycobacterial activity of human macrophages (Infect Immun 2009;77:5537)

CD23 was shown to be a low affinity receptor for IgE [4,5]. Similar to most FcR, soluble forms of CD23 (sCD23) are released into extracellular fluids. The soluble fragments formed by proteolytic cleavage of surface CD23 are not only capable of binding IgE (IgE binding factors) but also exhibit multiple functions that are not IgE related.

2016年5月16日 · The CD23 molecule is an Fc receptor specific for IgE (FcεRII) that is expressed on the surface of B cells and follicular dendritic cells in mice and in variety of hematopoietic cells in humans ...

CD23 is an integral membrane glycoprotein that plays a role in regulating the synthesis of IgE and has pro-inflammatory functions. It is expressed by activated B-cells, monocytes, follicular dendritic cells, and certain eosinophils and platelets. It is commonly found in chronic lymphocytic leukemia (CLL) cells and follicular cell lymphoma cells ...

2024年8月21日 · cd23 是一种种低亲和力 ige受体 ，在调节ige产生和 b细胞 分化中具有重要作用。 在b细胞上中，启动ige依赖性抗原摄取并呈递给t细胞。在巨噬细胞中，ige 结合和抗原交联通过激活l-精氨酸-一氧化氮途径触发细胞内杀死寄生虫。 cd23是一种 c型凝集素 。 它存在于成熟的b细胞、活化的巨噬细胞、嗜酸性粒 ...

IgE‐IC processing by CD23. CD23a, and CD23b are expressed in epithelial cells (A) which mediate endocytosis, transcytosis, and release of the chemokine CCL20 in response to CD23 triggering; in human primary B cells (B) which mediate endocytosis, recycling, and transport and in EBV B cells (C) which are capable of antigen degradation and IgE‐facilitated antigen‐presentation (FAP).

The R62W CD23 SNP is located in exon 4 of the fcεr2 gene . CD23 is a type-II integral membrane protein with a single transmembrane region and its carboxy-terminal region is therefore extracellular, while its amino-terminal domain is intra-cytoplasmic . The R62W SNP is in the extracellular portion of the protein, close to the transmembrane domain.

CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for intera …