2008年1月15日 · As CD2 physically interacts with both Lck and Fyn, preferentially inside lipid rafts, and reflecting the increase of CD2 in lipid rafts following activation, CD2 can mediate the …

2008年1月15日 · J.CaM1-CD2 cells expressing Lck(WT) or Lck(KD), a kinase defective mutant carrying a mutation at the ATP binding site, or Lck(C3A), an Lck mutant that has Cys 3 …

2022年8月5日 · To examine whether one or more of the proline-rich motifs of CD2 might recruit Lck, which bears an Src homology 3 domain capable of binding proline-rich motifs, pull-down …

2024年7月24日 · Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. …

2015年8月1日 · Lck and CD2 mRNAs were specifically expressed by clonal T cell lines, including both CD4 + and CD4 − CD8 − CTL lines, and in mixed lymphocyte cultures (MLC). Western …

Cytoplasmic domains of CD2 within highly concentrated microdomains, particularly poly proline regions, can activate Lck by competitively binding to autoinhibitory SH3 domain in Lck …

2008年3月1日 · Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2. J. Immunol. 180: 988–997 . In the Abstract, the year and volume are …

In mammals, Lck initiates signal transduction by binding to CD4 and CD8 co-receptors and phosphorylating ITAMs in the cytoplasmic tail of the CD3 molecules and the ζ chains. In …

2008年3月1日 · It is demonstrated that CD2 and p56lck associate when coexpressed in nonlymphoid cells, that this association requires the cytoplasmic domain of CD2, and that the …

2000年9月15日 · CD2 is a 50- to 55-kd glycoprotein expressed on a majority of thymocytes, T cells, and NK cells. Through physiologic interactions with its ligands CD58 (lymphocyte …