2023年7月10日 · Using patient-derived co-cultures, humanized mouse models, and single-cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we find that intact cancer cell-intrinsic expression of CD58 and ligation to CD2 is required for anti-tumor immunity and is predictive of treatment response.

2022年5月19日 · Previous work has found that downregulation of CD58, the co-stimulatory ligand for CD2, is associated with immune evasion in melanoma tumours and that ICB treatment of renal cell carcinoma is...

2023年6月15日 · We show that CD58 is crucial for infiltration of tumors by T cells, likely via its adhesive properties when ligated with CD2, and that increased CD58 co-stimulatory signaling via CD2 can enhance T cell activation and cytotoxicity.

In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a …

2024年11月5日 · CD58 loss in cancer cells leads to CAR T cell resistance and CD2-dependent T cell engagement in the tumor microenvironment is essential for sustained cytotoxicity. However, clinical evidence is sparse, and strategies to counteract this resistance are underdeveloped.

2020年9月14日 · CD2–CD58 interactions in the corolla boosted signaling by 77% as compared with central CD2–CD58 interactions. Engaged PD-1 invaded the CD2 corolla and buffered CD2-mediated amplification of TCR...

2023年10月9日 · The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell, Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and show an unexpected yin-yang link between PD-L1 and CD58.

2023年10月13日 · Our study highlights the CD2–CD58 axis-related immune signature as a valuable prognostic biomarker in LGG patients, with increased CD58 expression potentially serving as an immune evasion mechanism.

2021年6月8日 · In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a comprehensive summary of CD58 immunobiology.

6 天之前 · We discovered that TCR signalling is enhanced by CD2–CD58 interactions, whereas CAR sensitivity was increased by LFA1–ICAM1 adhesion. ... also showed how signals from the inhibitory receptor ...