CD169+ macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169+ macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs.

2023年3月28日 · Upon LPS and cecal slurry challenge, CD169+ macrophage-depleted mice exhibited overt inflammatory cytokine production and impaired interleukin-10 (IL-10) production. Importantly, we show that IL-10 production exclusively by CD169+ macrophages is critical for mediating protection against LPS shock.

Due to their unique location distribution in vivo and the presence of the CD169 molecule on their surfaces, CD169 + macrophages are reported to serve important roles in several processes, such as phagocytosis, antigen presentation, immune tolerance, viral …

2022年10月20日 · Using single-cell transcriptome analysis, we find that CD169 + macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells....

2011年12月16日 · Type 1 interferons are pleiotropic cytokines that secure an important first line of defense against viral infection. As many viruses replicate rapidly, the interferon system must react...

CD169 + macrophages are responsible for the capture of pathogens and are frequently the first cell type infected and thereby provide a confined source of antigen. Subsequently, cross-presenting DCs interact with these antigen-containing CD169 + macrophages, pick up antigens and activate T cells.

CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated molecular structures, which are found among various pathogenic and non-pathogenic ligands.

2021年5月13日 · We aimed to evaluate SIGLEC1 (CD169) as a biomarker in multiple sclerosis (MS) and Neuromyelitis optica spectrum disorder (NMOSD) and to evaluate the presence of SIGLEC1 + myeloid cells in...

2011年12月22日 · CD169+ macrophages have fascinated immunologists because of their unique distribution in secondary lymphoid organs, redistribution upon immune activation and, lately, because of their contribution to antigen handling.

2021年4月13日 · CD169 + LN macrophage depletion, using an anti-CSF-1R antibody or clodronate-loaded liposomes, leads to increased metastatic burden in two mouse breast cancer models.