Tissue factor, also called platelet tissue factor or Coagulation factor III, [5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene. Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin.

2024年7月1日 · 组织因子（TF），又称为凝血因子III（Coagulation factor III）或CD142，在人类中由位于1号染色体p21.3的F3基因编码，长度约为12.4kb。 编码组织因子TF蛋白的序列由六个外显子组成。

2024年2月15日 · 组织因子 （Tissue Factor， TF ） ，也称为凝血组织因子或CD142，是一种参与血液凝血过程的膜蛋白，能够与凝血酶原活化物 VIIa （fVIIa） 协作启动凝血级联反应，导致凝血酶生成、纤维蛋白形成，并通过受体激活血小板等效应细胞 【1】 。

Tissue Factor (TF)/CD142 (Coagulation factor III/Thromboplastin) is a type-I transmembrane glycoprotein that serves as the cell surface receptor and cofactor for blood coagulation factors VII and VIIa, and thus plays a central role in hemostasis and thrombosis (1).

CD142 is expressed on the surface of multiple malignant tumors and contributes to carcinogenesis. However, the role of CD142 in the pathogenesis of gastric adenocarcinoma (GAC) remains unclear. This study aimed to investigate the role of CD142 in GAC carcinogenesis.

Tissue Factor Protein, Human (HEK293, Fc)是一种在 HEK 293 细胞中表达的，C 末端有 Fc 标签的重组人 CD142。 Coagulation Factor III/CD142 Protein 是致癌新血管生成的主要调节剂，可控制癌变过程。

An analysis of the proportion of CD142 + cells in desmoid tumors and prognosis would be an interesting clinical study. CD142, also called TF, is a member of the blood coagulation cascade, but recent evidence suggests it may also be involved in additional cellular signaling important for tumor growth . Structurally, CD142/TF shares an ...

Description: This HTF-1 monoclonal antibody reacts with human CD142, which is also known as Tissue Factor. Expression of this type I transmembrane glycoprotein on endothelial cells, monocytes, macrophages, and platelets can be induced by inflammatory mediators (e.g., LPS, IL-1b, TNFa, PMA, or endotoxin).

CD142, also named tissue factor, factor III, or thromboplastin, is a transmembrane glycoprotein that is essential for the coagulation cascade. When coagulation factor VII binds to CD142, it is converted to the active form factor VIIa, which in turn stimulates the activation of factors IX and X.

3 天之前 · Tissue Factor (TF)/CD142 (Coagulation factor III/Thromboplastin) is a type-I transmembrane glycoprotein that serves as the cell surface receptor and cofactor for blood coagulation factors VII and VIIa, and thus plays a central role in hemostasis and thrombosis (1).