CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . [5] [6] CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a ...

The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1).CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs). The principle point to note is that CD11c + DCs are located mainly within, and at the outer borders of, T-cell areas in spleen.

Abstract. CD11c + T-bet + atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive. A major obstacle in the study of ABCs, and human MBCs more generally, has been the use of different phenotypic markers in different contexts to identify …

Jan 9, 2025 · CD11c dendritic cells can present antigens in a manner that promotes the development of Tregs, thereby preventing the activation of potentially autoreactive T cells. Another mechanism by which these dendritic cells contribute to immune tolerance is through the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades tryptophan.

CD11c expression is a marker of microglia activation and the presence of CD11c + microglia around Aβ plaques in Alzheimer’s disease (AD) has been shown in several studies (reviewed in Benmamar-Badel et al., 2020). Microglial CD11c expression near plaques is also detected in the APP/PS1 AD models as confirmed through co-staining with the ...

The CD11c dendritic cell marker is one such identifier, a beacon that highlights a critical cell group involved in our fight against diseases. The Importance of CD11c as a Dendritic Cell Marker. CD11c, a subtype of the integrin alpha X protein, is a widely recognized dendritic cell marker. While it’s not exclusively present on these cells ...

Jan 18, 2022 · CD11c + and CD11c − macrophages equally expressed MHCII, CD11b, the macrophage marker F4/80, and CD14 (Fig. 1c). CD11c − macrophages also more strongly expressed MerTK and the mannose receptor ...

Jun 26, 2018 · CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4. However, the functions of this prominent marker protein in DCs, especially in vivo, remain poorly defined.

Dec 9, 2020 · CD11c is a complement receptor classified as complement receptor 4 and binds to iC3b in vitro. 59 C3 and C5 are involved in HSPC mobilization and homing. 60-62 C3 cleaved fragments (C3a, desArg C3a, iC3b) increase in the bone marrow during mobilization. 63 Fibrinogen and LPS are also reported as CD11c ligands in vitro, where fibrinogen has been ...

Apr 3, 2023 · CD11c/CD18 (CD11c is named αX; CD11c/CD18 is also called αXβ2, complement receptor 4 [CR4], p150,90; gene Itgax) is a member of the leukocyte adhesion molecule integrin family called β2 integrins and is primarily considered a marker and a major adhesion receptor of dendritic cells (DCs). 19 However, CD11c messenger RNA expression (Itgax ...