Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein. [5] This gene encodes a …

2021年9月10日 · CD112 is easily detectable on antigen-presenting or tumor cells, and its high level of expression has been linked with tumor progression and poor outcomes in most cancer …

Nectin-2 (CD112)多种类型的肿瘤中（例如 急性髓细胞性白血病 、 多发性骨髓瘤 和 上皮癌）表达上调。 CD112与 胆囊癌 的侵袭和预后不良相关，同时也有研究发现，CD112可能在CD155不 …

2022年5月13日 · CD112也称为连接蛋白-2或PVR相关蛋白2（PVRL2），是连接蛋白家族的成员，与肿瘤血管生成、生长和转移相关。 CD112包括一个具有三个Ig样结构域（两个IgC和一个 …

CD112 might facilitate the acquisition of mesenchymal traits by cancer cells, thus enhancing their motility, invasiveness, and metastatic potential. Collectively, aberrant CD112 expression in …

CD112R是免疫细胞表达的免疫球蛋白超家族受体，与肿瘤细胞表达的 Nectin-2/Necl 家族配体（CD112）相互结合，在肿瘤免疫治疗中具有很大的潜力，是新一代的抑制性免疫检查点。 …

2016年2月8日 · In this study, we describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for human T cells. CD112R is preferentially expressed on T …

2024年5月31日 · Western blotting and pathway enrichment analysis showed that CD112 is significantly linked to epithelial-to-mesenchymal transition (EMT). Additionally, CRC cells …

CD112 is easily detectable on antigen-presenting or tumor cells, and its high level of expression has been linked with tumor progression and poor outcomes in most cancer patients. This …

CD112 is easily detectable on antigen-presenting or tumor cells, and its high level of expression has been linked with tumor progression and poor outcomes in most cancer patients. This …