Flow cytometric analysis of LAIR-1 (CD305) expression on human peripheral lymphocytes. Whole blood was stained with either PE Mouse Anti-Human LAIR-1 (CD305) (Cat. No. 550811; solid line histogram) or PE Mouse IgG1, κ Isotype Control (Cat. No. 555749; dashed line histogram). Erythrocytes were lysed with Pharm Lyse™ Lysing Buffer (Cat. No. 555899).

2023年8月8日 · Ov er al l, CD 305 wa s down-re g ula te d i n 155/ 172(90. 1%) c as es. CD305. wa s indis pe nsa ble i n the de te c tio n of occ ult BM i nv olv em ent in 56(37.6%) c a se s whic h, la ck ed othe r.

As part of this application, the courses of CD 225, CD 244, CD 275, CD 277, CD 305 and CD 351 must have a combined GPA of 3.0. Prerequisite(s) with concurrency: CD 443 Writing

2020年3月29日 · Leukocyte associated immunoglobulin like receptor-1 (LAIR-1) or (CD 305) expressed by B-cells as an immune inhibitory marker of B cell receptor (BCR)-mediated...

2014年1月10日 · The expression of LAIR1 (also known as LAIR-1 or CD305), an inhibitor of B-cell receptor -mediated signaling, has been reported to lack in high-risk chronic lymphocytic leukemia. However, its...

CD305 is a type I transmembrane glycoprotein that possesses an extracellular Ig-like domain and two intracellular ITIMs. CD305 is expressed on nearly all immune cells, including T, NK, and B cells, as well as monocytes, dendritic cells, eosinophils, basophils, and mast cells.

2016年12月2日 · To functionally explain the peculiar clinical behavior of CLL expressing these molecules, we evaluated CLL cell response to BCR triggering in CD305 + /CD307b bright CLL, with either a M (n=9) or a UM (n=7) IGHV gene status.

Human peripheral blood mononuclear cells (PBMCs) were stained with CD305 (LAIR-1) antibodies or with the corresponding REA Control (S) antibodies (left image) as well as with CD19 antibodies. Flow cytometry was performed with the MACSQuant® Analyzer. Lymphocytes were pregated for the analysis.

CD305, also called LAIR1 (Leucocyte-associated Ig-like receptor 1), is a 31 kDa type 1 transmembrane molecule with a single N terminal extracellular Ig superfamily C2 domain. The extracellular domain contains one N-glycosylation site. CD305 is expressed on the majority of lymphocytes, NK cells, monocytes, dendritic cells and naïve B cells.

Mouse anti Human CD305 antibody, clone NKTA255 recognizes human leukocyte-associated Ig-like receptor-1 (LAIR-1), a ~40 kDa cell surface molecule that functions as an inhibitory receptor on natural killer cells, monocytes and T cells.