Apr 14, 2022 · CCT2 associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical VLIR …

Apr 2, 2022 · CCT2是分子伴侣Chaperonin复合体的一个亚基，与复合体一起作为分子伴侣帮助错误折叠的蛋白正确地折叠。 研究发现，CCT2是以单体形式介导聚集体自噬的，因为只有单体 …

Mar 30, 2025 · CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include Aniridia 1 and Leber Plus Disease. Among its related …

Dec 8, 2016 · Knockdowns of CCT complex subunits (CCT2/5/7) increased the number and size of autophagosomes/non-acidified lysosomes (yellow vesicles/GFP dots), while the number of …

Apr 5, 2022 · In particular, CCT2 — a subunit of the chaperonin TRiC complex — was implicated in aggregate removal by autophagy both in vitro and in mouse brain. Like ubiquitin-binding …

2022年4月1日，清华大学生命学院葛亮课题组在 Cell 期刊在线发表题为：CCT2 is an aggrephagy receptor for clearance of solid protein aggregates的研究论文。该研究发现了一种新型的聚集体 …

CCT2, traditionally viewed as a molecular chaperone, has emerged as a novel autophagy receptor that specifically targets solid protein aggregates for degradation. This ubiquitination …

Apr 1, 2022 · Here, we identify the chaperonin subunit CCT2 as an autophagy receptor regulating the clearance of aggregation-prone proteins in the cell and the mouse brain. CCT2 associates …

A recent study from Ge lab reported the TRiC subunit CCT2 (chaperonin containing TCP1 subunit 2) as the first identified specific aggrephagy receptor in mammals. The switch of CCT2's role …

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene. [5][6] This gene encodes a molecular chaperone that is member of the TRiC complex. This complex …