C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. [5] [6] [7] CCR4 has also been designated CD194 (cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2 (MCP-1) CCL4 (MIP-1) CCL5 (RANTES ...

ccr4作为肿瘤转移中关键的趋化因子受体，多项研究已证实，ccr4高表达与血液系统肿瘤以及恶性实体瘤的浸润和预后密切相关，靶向ccr4有望成为恶性肿瘤免疫治疗的新策略。

2025年3月30日 · CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Mycosis Fungoides and Peripheral T-Cell Lymphoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

收集野生型c57bl/6和纯合b-hccr4小鼠的脾细胞，并用种属特异性抗ccr4抗体进行流式细胞术分析。 结果显示：鼠CCR4仅在野生小鼠中检测到，人CCR4仅在纯合B-hCCR4小鼠中检测到。

CCR4 is a chemokine receptor selectively expressed on normal T cell subsets such as type 2 helper T cells, skin-homing T cells and regulatory T cells, and on skin-associated T cell malignancies such as adult T cell leukemia/lymphoma (ATLL), which is etiologically associated with human T lymphocyte virus type 1 (HTLV-1), and cutaneous T cell ...

CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs)-CCL17 (also called thymus- and activation-regulated chemokine) and CCL22 (macrophage-derived chemokine). Among the various T-cell subsets, CCR4 is predominantly expressed by Th2 cells, cutaneous lymphocyte antigen-positive skin-homing T cells and Treg cells.

2024年9月19日 · cc 趋化因子受体 4(ccr4)是一种蛋白质，由 ccr4 基因编码。该基因所编码的蛋白属于 g 蛋白偶联受体家族。 趋化因子 是一组结构相关的小蛋白，调节各种类型白细胞的细胞贩运。趋化因子在免疫系统的发育、平衡和功能方面也发挥着基本作用，它们对中枢神经系统 ...

Findings suggest that C-C motif chemokine receptor 4 (CCR4) may be a potential new diagnostic and prognostic marker in hepatocellular carcinoma (HCC), and targeting CCR4 may be a potential therapeutic option for blocking HCC metastasis

2021年11月4日 · CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. Later, its expression was extended to other T cell subsets such as regulat …

2014年8月2日 · CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs)—CCL17 (also called thymus- and activation-regulated chemokine) and CCL22 (macrophage-derived chemokine). Among the various T-cell subsets, CCR4 is predominantly expressed by T h 2 cells, cutaneous lymphocyte antigen-positive skin-homing T cells and T …