2021年12月23日 · In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, and presented three cryogenic-electron...

2023年11月1日 · Pathway analyses found that CCR3 activation triggers the Gq-PLC-Ca 2+ and MAPK-P38 pathways. By high-throughput screening and virtual screening of a library of TCM-derived compounds, we identified emodin as a novel CCR3 antagonist.

由该基因编码的蛋白质是 CC 型趋化因子的受体。 它属于 G 蛋白偶联受体家族 1。 该受体结合并响应多种趋化因子，包括嗜酸细胞趋化因子 (CCL11) 、嗜酸细胞趋化因子 3 (CCL26) 、MCP-3 (CCL7) 、MCP-4 (CCL13) 和 RANTES (CCL5) 。 它在嗜酸性粒细胞和嗜碱性粒细胞中高表达，也在 TH1 和 TH2 细胞以及气道上皮细胞中检测到。 该受体可能有助于过敏性气道中嗜酸性粒细胞和其他炎症细胞的积累和激活。 它也被认为是 HIV-1 的进入辅助受体。 该基因和其他七个趋化 …

为了构建高通量筛选模型，我们建立了稳定转染的cho-k1-gα15-ccr3细胞系，并通过实时定量pcr、共聚焦检测和流式细胞术分析来证明受体表达。 然后，我们应用无标记细胞表型分析技术对 CHO-K1-Gα15-CCR3 细胞中的 CCR3 靶途径进行分析和解卷积，发现 CCR3 的激活触发了 ...

2022年5月15日 · Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human...

2025年3月30日 · CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Aids Dementia Complex and Esophagitis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2013年8月27日 · Chemokine (C-C motif) ligand 5 (CCL5) acts at C-C chemokine receptors (CCRs) to promote immune cell recruitment to sites of inflammation, but is also an agonist at G-protein-coupled receptor 75 (GPR75), which has very limited homology with CCRs.

浙江大学医学院附属第一医院马量老师团队在《Cell Biol Toxicol》发表了题目为：CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation的研究论文，本研究旨在探讨多效性趋化因子CCL24在心力衰竭中的作用机制。

2023年10月1日 · CC chemokine receptor 3 (CCR3) plays important roles in atopic dermatitis (AD) and other related allergic diseases. Activation of CCR3 receptor signaling pathways regulates the recruitment of eosinophils to related tissues, releasing inflammatory mediators and causing inflammatory responses.

2000年12月15日 · This study shows that platelets have functional CCR1, CCR3, CCR4, and CXCR4 chemokine receptors. Polymerase chain reaction detected chemokine receptor messenger RNA in platelet RNA. CCR1, CCR3, and especially CCR4 gave strong signals; CXCR1 and CXCR4 were weakly positive.