G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. [5] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members …

Mar 30, 2025 · CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Pancreatic Cancer and Ovarian Cancer. Among its related pathways are Defective …

Apr 20, 2022 · To uncover therapeutic targets for tumours with CCNE1 amplification, we undertook genome-scale CRISPR–Cas9-based synthetic lethality screens in cellular models of …

Mar 24, 2023 · Our study demonstrated that CCNE1 is upregulated in multiple cancers in the TCGA database and may be a promising predictive biomarker for the immunotherapy …

Apr 1, 2025 · Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with CCNE1-amplification are often resistant to standard treatment and represent an unmet clinical need. …

Here, we review the current understanding of one of the most common genetic alterations in epithelial ovarian cancer, CCNE1 (cyclin E1) amplification, and its role as a potential predictive …

May 29, 2024 · Recent studies suggest that CCNE1 amplification is a potential target for new synthetic lethality-based treatments, including CDK2-selective and PKMYT1 inhibition. This …

Sep 21, 2021 · These studies demonstrate that CCNE1 CN is a clinically tractable biomarker predicting responsiveness to low-dose WEE1i-ATRi for aggressive subsets of OVCAs/EMCAs. …

Feb 24, 2025 · Cyclin E1 (CCNE1) amplification is associated with poor prognosis of ovarian carcinomas across histological subtypes. Inhibitors targeting PLK1 or WEE1 are emerging as …

Feb 9, 2025 · CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma. Cyclin E1 expression and malignancy in meningiomas. Reduced RBX1 expression …