CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1. [9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells.

2024年12月24日 · CCL8 (C-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include Tenosynovitis and Tendinitis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

2019年11月20日 · In this study, we demonstrate that chemokine (C-C motif) ligand 8 (CCL8) is highly expressed by TAMs and contributes to pseudopodia formation by GBM cells. The presence of CCL8 in the glioma...

2011年1月9日 · Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MCP) family whose biological activity and receptor usage have remained elusive. Here we show that CCL8 is highly expressed...

2017年12月28日 · This study delivers a simple and applicable way to produce functional chemokines in E. coli. The results clearly confirms that CCL8 can interact with chemokine receptor CCR3, therefore, it is promising area to develop drugs for …

2025年1月7日 · We identified CCL8 as a critical mediator of the GAS6/AXL/MERTK pathway, primarily by inhibiting Treg infiltration into the tumor. Furthermore, the AXL/MERTK signaling blockade sensitized tumor cells to anti-programmed cell death 1 (anti-PD-1) treatment.

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling. Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer.

2022年8月22日 · CCL8 has been implicated in macrophage recruitment in several solid tumors, and only a few reports have been published on the role of CCL8 in the pathogenesis of hematological malignancies. This article attempted to find out TME-related genes that associated with the survival in DLBCL patients.

2025年1月4日 · CCR8, the receptor for mouse CCL8 (an analog of human CCL18) and CCL1, is a G protein–coupled receptor expressed on T helper 2 cells, regulatory T cells, NK cells, basophils, eosinophils, macrophages, and monocytic …

2022年12月22日 · CCL8 (MCP-2) is a chemoattractive cytokine associated with various immune-related pathologies. Recent studies show that CCL8 is significantly stimulated during acute respiratory distress syndrome in severely ill patients with COVID-19, making the inhibition of CCL8 activity a promising treatment.