
CCL7 recruits cDC1 to promote antitumor immunity and facilitate ...
2020年11月30日 · CCL7 deficiency impairs the infiltration of cDC1 in the TME and the subsequent expansion of CD8+ and CD4+ T cells in bronchial draining lymph nodes and TME, …
Nature子刊:钟波/褚倩研究组揭示趋化因子通过调节免疫微环境提 …
基于ccl7在重塑非小细胞肺癌免疫微环境中的重要功能,该联合团队提出ccl7可能提升pd-1抗体介导的免疫检查点治疗nsclc的疗效。 研究团队通过PD-1抗体单药治疗,CCL7联合PD-1抗体治 …
《自然·通讯》发表钟波教授团队非小细胞肺癌重要研究成果
2020年12月1日 · 该文阐述了趋化因子CCL7招募cDC1促进抗肿瘤免疫的重要功能与机制,为治疗非小细胞肺癌提供新的免疫检查点疗法。 生命科学学院2016级博士研究生张满和医学研究 …
CCL7 recruits cDC1 to promote antitumor immunity and facilitate ...
2020年11月30日 · Administration of CCL7 into lungs alone or in combination with anti-PD-1 significantly inhibits tumor development and prolongs the survival of KP and KL mice. These …
前沿透视 | Cell: 卵巢癌细胞来源的IL-4促进免疫抑制和免疫治疗抵 …
2024年11月28日 · CCL7的缺失通过构建免疫排斥和内皮细胞减少的TME促进卵巢癌的生长. 该研究发现ID8细胞中Ccl7敲除组是Perturb-map分析中富集程度最高的克隆,这表明趋化因子 …
Combined targeting of CCL7 and Flt3L to promote the expansion …
2023年3月9日 · These data together suggest that the CCL7 component of PD-1Ab7 promotes the chemotaxis of cDC1s and thereby synergizes with the anti-PD-1 component of PD-1Ab7 to …
什么是趋化因子配体7(CCL 7)? - 知乎
ccl7对多种白细胞具有强效的趋化吸引作用,如单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、树突状细胞(dc)、nk细胞和活化的t淋巴细胞。 CCL7将白细胞招募到受感染的组织中,应对入侵 …
CCL7 promotes the chemotaxis of cDC1 into the TME which subsequently facilitates T cell expansion and antitumor immu-nity. Consistently, combination of CCL7 and anti-PD-1 treatment
CCL7募集cDC1来促进抗肿瘤免疫力并促进非小细胞 ... - X-MOL
Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the LSL−G12D/+ fl/fl (KP) and the (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into the TME to …
趋化因子CCL7的研究进展 - shsmu.edu.cn
Chemokine (C-C motif) ligand 7 (CCL7) is widely expressed in fibroblasts, monocytes and tumor cells, and exerts a spectrum of functions as monocyte recruitment, elicitation of...