C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene. [4] [5] [6] The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. [7]

2025年3月30日 · CCL22 (C-C Motif Chemokine Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include Eosinophilic Pneumonia and Dermatitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

Studying a newly established CCL22-deficient mouse, we demonstrate that CCL22 expression by dendritic cells (DCs) promotes the formation of cell–cell contacts and interaction with regulatory T cells (T reg) through their CCR4 receptor.

CCL22 controls T cell immunity, both by recruiting T regs to the tumor tissue and by promoting the formation of DC-T reg contacts in the lymph node. Here, we review the current knowledge on the role of CCL22 in cancer immunity.

CCL22 could be an immune marker in ANCA-associated vasculitis. Suggest that lower CCL22 levels may play an important role in the pathogenesis of multiple sclerosis in women. CCL22 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus.

CCL22 is a macrophage-derived chemokine [36] but is also produced by cancer cells, dendritic cells (DC), and tumor-associated macrophages (TAM) [37–41]. It can recruit regulatory T cells (Tregs) into tumor tissues and enhance tumor immune escape mechanisms.

2019年5月6日 · Studying a newly established CCL22-deficient mouse, we demonstrate that CCL22 expression by dendritic cells (DCs) promotes the formation of cell-cell contacts and interaction with regulatory T cells (T reg) through their CCR4 receptor.

We investigated mutational profiles, including CCL22 gene mutations, in patients with LGL leukemia and identified CCL22 mutations in T-cell LGL (T-LGL) leukemia and NK-LGLL, and found that their associations with clinical features varied among the subtypes of LGL leukemia.

2020年10月15日 · CCL22 is a key mediator of leukocyte trafficking in inflammatory immune responses, allergy, and cancer. It acts by attracting regulatory T cells and Th2 cells via their receptor CCR type 4 (CCR4).

C–C chemokine ligand 22 (CCL22), also known as Macrophage-derived chemokine (MDC), is expressed in dendritic cells, macrophages, and activated monocytes . Mature CCL22 induces chemotaxis or Ca 2+ activation in NK cells, activated T lymphocytes and dendritic cells .