Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. [5]

Mar 30, 2025 · CCL20 (C-C Motif Chemokine Ligand 20) is a Protein Coding gene. Diseases associated with CCL20 include Sialadenitis and Psoriasis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

Feb 22, 2025 · CCL20, a chemokine best known to induce leucocyte migration in response to pathological and inflammatory conditions, has been implicated in tumor proliferation, angiogenesis, metastasis, immunosuppression, and therapeutic resistance.

Dec 27, 2024 · In this review, we delve into the potential roles of the CCL20-CCR6 axis within the respiratory system by synthesizing and analyzing current research findings. Our objective is to provide a comprehensive understanding of the CCL20-CCR6 axis and its implications for respiratory health and disease.

Dec 5, 2016 · CC-chemokine ligand 20 (CCL20), a ligand of CC-chemokine receptor 6 (CCR6) which is its only receptor, plays an important role in various pathologic conditions. CCL20 and CCR6 are exploited by cancer cells for migration and metastasis and play important roles in the development and progression of cancer .

Jul 27, 2018 · We found that a secretory protein called C-C motif chemokine ligand 20 (CCL20) responds to taxane chemotherapy in TNBC and promotes the expression of a drug efflux pump through a specific signaling pathway (CCL20-protein kinase Cζ [PKCζ]/p38 mitogen-activated protein kinase [MAPK]-nuclear factor kappa B [NF-κB]-ATP-binding cassette subfamily ...

Feb 15, 2020 · This chapter will review and discuss the regulation of CCL20 on various cancers, the remodeling of tumor microenvironment mediated by CCL20, the synergistic regulation of CCL20 and other factors on microenvironment, and the activation and transmission of CCL20 signaling in tumor microenvironment.

CCL20 was secreted in a hypoxia-dependent manner from astrocytes and busted the hypoxic induction of HIF-1α in glioblastoma cells. Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa …

Jul 14, 2013 · CCL20 and Its Receptor in an Inflammatory Environment. The up-regulation of CCL20 in inflammation has been documented well in the literature. Under experimental conditions, various cytokines (IL-1α, IL-β, IL-17, IL-21, IFN-γ, TNF-α) have been found to induce CCL20 expression at various micro-anatomical locations (34– 36).

Emerging studies have demonstrated notable roles of CCL20 in breast cancer progression. Based on these findings, CCL20 has become a potential therapeutic target for cancer immunotherapy. Accordingly, studies utilizing monoclonal antibodies to …