Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family.

CCL20，C-C趋化因子配体20，又称为巨噬细胞炎症蛋白-3α（MIP-3α），大小约8kDa，由位于人类2号染色体上的SCYA20基因编码。 CCL20可在肠道、肺部、肝脏和淋巴组织（淋巴结和派尔氏斑）等外周器官组织中发现持续表达。

2025年3月30日 · CCL20 (C-C Motif Chemokine Ligand 20) is a Protein Coding gene. Diseases associated with CCL20 include Sialadenitis and Psoriasis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.

三个基因在肿瘤中的表达显著高于正常样本（图2D），生存分析表明GJB2、CCL20高表达样本有更差的生存时间更短（图2EF），KRT24则相反是保护因子（图2G）。 随后对他们进行了时间依赖ROC分析，发现GJB2、CCL20是出色的预后预测因子，表现普通（图2HI）。

CCL20 binds to and acts as a chemokine receptor CCR6 and synergistically inhibits the function of CD8 T cells with CCR6. CCL20 has antimicrobial activity and has been implicated in autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis, as well as oncological diseases.

CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins.

2020年7月22日 · The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor microenvironment through immune cell control. The present article reviewed the role of the CCL20-CCR6 axis in cancer progression and its potential as a therapeutic target.

2024年10月29日 · CCL20作为趋化因子，其主要功能是吸引和激活特定的免疫细胞，包括淋巴细胞、树突状细胞和轻微的中性粒细胞。 它通过与趋化因子受体CCR6结合，在炎症部位和淋巴组织中发挥关键作用。

2023年3月5日 · 2023年3月1日，柳素玲团队在Signal Transduction and Targeted Therapy杂志在线发表了题为PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2...

2024年12月3日 · 趋化因子配体20（CCL20），也被称为巨噬细胞炎症蛋白3α（MIP-3α）和肝激活调节趋化因子（LARC），是一种属于CC趋化因子家族的小分子量细胞因子。 以下是对CCL20的详细解析： CCL20的生理功能