IRF7: role and regulation in immunity and autoimmunity - PMC
Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed …
IRFs: master regulators of signalling by Toll-like receptors and ...
2006年9月1日 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine …
Acetylation of interferon regulatory factor-7 by p300/CREB …
2002年12月20日 · Interferon regulatory factor 7 (IRF7) is an interferon-inducible transcription factor required for induction of delayed early interferon alpha genes and the onset of a potent …
Direct Inhibition of IRF-Dependent Transcriptional Regulatory ...
These results suggest that IRF7 is a modulator of neointima formation during atherosclerosis. In addition, IRF7 regulated genes were highly expressed in breast cancer patients with a …
Acetylation of Interferon Regulatory Factor-7 by p300/CREB …
2002年12月20日 · Here, we report that IRF7 is acetylated in vivo by the histone acetyltransferases p300/CBP-associated factor (PCAF) and GCN5. The single lysine residue …
The multiple roles of interferon regulatory factor family in health …
2024年10月9日 · IRF proteins regulate the expression of target genes through their interaction with ISREs or IFN regulatory elements within the DNA. All IRFs feature a highly conserved N …
IRF7 inhibition prevents destructive innate immunity—A
We identify the transcription factor interferon regulatory factor 7 (IRF-7), a heterodimer partner of IRF-3, as a target for non–antibiotics-based therapy of bacterial infections. We found that the …
IRF7 interferon regulatory factor 7 [ (human)] - National Center …
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional …
Interferon regulatory factor-7 synergizes with other transcription ...
2003年5月2日 · Interferon regulatory factor (IRF)-7 is activated in response to virus infection and stimulates the transcription of a set of cellular genes involved in host antiviral defense. The …
Mechanism for transcriptional synergy between interferon …
The interferon-beta promoter has been studied extensively as a model system for combinatorial transcriptional regulation. In virus-infected cells the transcription factors ATF-2, c-Jun, …