2020年9月8日 · Using the multi-dendritic PVD neuron in the nematode Caenorhabditis elegans, we identify CATP-8/P5A ATPase as a key regulator of dendrite branching that controls the translocation of the DMA-1 receptor to the endoplasmic reticulum (ER). The specific signal peptide of DMA-1 and the ATPase activity of CATP-8 are essential for this process.

2018年3月16日 · The expression patterns of the native FP-fusions are very similar to those observed using extrachromosomal transgenes. CATP-6::FP is expressed in a punctate pattern in many neurons in the head and tail, all body wall muscles, the posterior gut, the spermatheca, the DTC and the pharyngeal cells (Fig 4B and below). CATP-6::FP is also expressed in ...

2020年9月8日 · Using the multi-dendritic PVD neuron in the nematode Caenorhabditis elegans, we identify CATP-8/P5A ATPase as a key regulator of dendrite branching that controls the translocation of the DMA-1 receptor to the endoplasmic reticulum (ER). The specific signal peptide of DMA-1 and the ATPase activity of CATP-8 are essential for this process.

CATP-8 controls the translocation of Wnt proteins into the endoplasmic reticulum through the hydrophobic cores in Wnt signal sequences. This study provides insights into the physiological functions of P5A-ATPases in neuronal patterning and reveals potential mechanisms underlying P5A-mediated transportation.

2021年10月26日 · Here, we report that CATP-8/P5A ATPase directs neuronal migration non-cell autonomously in Caenorhabditis elegans by regulating EGL-20/Wnt biogenesis. CATP-8 likely functions as a translocase to translocate nascent EGL-20/Wnt polypeptide into the ER by interacting with the highly hydrophobic core region of EGL-20 signal sequence.

2021年7月1日 · We show here, that the Caenorhabditis elegans ortholog catp-8/P5A-ATPase is required for defined aspects of nervous system development. Specifically, the catp-8/P5A-ATPase serves functions in shaping the elaborately sculpted …

在筛选神经系统模式所需的基因时，我们确定了catp-8 / P5A-ATPase是神经模式的重要调节剂。 P5A-ATPase是P型ATPase的一部分，P型ATPase是一类蛋白质，已知在单细胞真核生物，植物和人类中起离子，脂质和多胺的转运蛋白的保守功能。

2021年7月1日 · 遗传分析表明，catp-8/P5A-ATPase 可以在多种途径中发挥作用，包括 Menorin 途径（之前显示可控制 PVD 中的树突状模式）和 Wnt 信号传导（其功能可控制神经元迁移）。

2018年3月16日 · By using CRISPR/Cas9, we have systematically investigated the expression patterns, subcellular localization and biological functions of each of the P5B ATPases of C. elegans. We find that each gene...

2021年7月1日 · In screens for genes required for patterning of the nervous system, we identified the catp-8/P5A-ATPase as an important regulator of neural patterning. P5A-ATPases are part of the P-type ATPases, a family of proteins known to serve a conserved function as transporters of ions, lipids and polyamines in unicellular eukaryotes, plants, and humans.