2025年3月28日 · Complete information for C4A gene (Protein Coding), Complement C4A (Chido/Rodgers Blood Group), including: function, proteins, disorders, pathways, orthologs, and expression.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion.

Complement C4 is the most polymorphic protein in complement system. A plethora of research data demonstrated that individuals with C4 deficiency are prone to microbial infections and autoimmune disorders. In this review, we will discuss the diversity of complement C4 proteins and its genetic structures.

Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components.

2025年2月8日 · This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion.

2024年8月1日 · Complement C4 protein is expressed as two isotypes, C4A and C4B, which are encoded by the C4 genes (C4A or C4B gene), and share >99% sequence identities. The difference lies in four isotype-specific amino acid substitutions at amino acid positions 1120–1025 (C4A: 1120PC PV LD1125; C4B: 1120LS PV IH1125).

2023年7月18日 · The complement component 4 gene locus, composed of the C4A and C4B genes and located on chromosome 6, encodes for C4 protein, a key intermediate in the classical and lectin pathways of the complement system.

2024年4月13日 · This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion.

2001年3月1日 · Human C4 is the most polymorphic protein of the complement system. In this review, we summarize the current concepts on the 1–2–3 loci model of C4A and C4B genes in the population, factors affecting the expression levels of C4 transcripts and proteins, and the structural, functional and serological diversities of the C4A and C4B proteins.