C3b 与细胞表面碳水化合物或免疫聚集体共价结合，而 C3a 作为炎症介质，诱导中性粒细胞趋化并促进平滑肌收缩、增加血管通透性和组胺释放。较短的 C3a 异构体可刺激 B 细胞 …

It catalyzes the proteolytic cleavage of C3 into C3a and C3b, generated during activation through the classical pathway as well as the lectin pathway. C3a is an anaphylotoxin and the precursor …

补体C3（Complement 3，C3），是种由肝脏合成的β₂球蛋白，由α和β两条多肽链组成。C3是血清中含量最高的补体成分，在C3转化酶的作用下，裂解成C3a和C3b两个片段，在补体经典激活 …

As the most abundant component of the complement system, C3 and its proteolytic derivatives serve essential roles in the function of all three complement pathways. Central to this is a …

In this study, with an aim to gain more insights into the function of teleost C3 and C3a, we examined the biological role of Japanese flounder (Paralichthys olivaceus) C3 (PoC3) and …

C3是血清中含量最高的补体成分，主要由巨噬细胞和肝脏合成，在C3转化酶的作用下，裂解成C3a和C3b两个片段，在补体经典激活途径和旁路激活途径中均发挥重要作用。

2005年9月22日 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we …

Although C3a binds to the anaphylatoxin receptor C3aR, C3b and its degradation products iC3b and C3dg interact with a variety of complement receptors (CR) to mediate immune adhesion, …

2023年3月7日 · C3是血清中含量最高的补体成分，主要有巨噬细胞和肝脏合成，在C3转化酶的作用下，裂解成C3a和C3b两个片段，在补体经典激活途径和旁路激活途径中均发挥…

Complement component 3 (C3) is a key complement protein and its cleavage into C3a and C3b is central to all three complement pathways. Indeed, mice eyes develop many features of AMD …