2021年8月16日 · We found that the complements C3, C5, C3AR1, and C5AR1 have deregulated expression in human malignancies and are associated with activation of immune-related oncogenic processes and poor prognosis of cancer patients.

We used multi-omics approaches to evaluate the association of complement signature C3/C5/C3AR1/C5AR1 with tumor immune phenotypes and prognosis across various cancer types. We found that the gene signatures have deregulated expression in human ...

2025年3月28日 · C3AR1 (Complement C3a Receptor 1) is a Protein Coding gene. Diseases associated with C3AR1 include Atypical Hemolytic-Uremic Syndrome and Prostate Cancer. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Complement cascade.

2022年9月15日 · Here, we show that the right ventricle predominantly expresses alternative complement pathway-related genes, including Cfd and C3aR1. Complement 3 (C3)-knockout attenuates right ventricular...

2025年2月8日 · High C3aR1 expression is associated with acute myeloid leukemia-M2. these findings suggest a critical role for C3a through autocrine/paracrine induction of C3aR in the pathogenesis of cigarette smoke-induced sterile inflammation and provide new therapeutic targets for the treatment of emphysema.

2023年5月11日 · These structures, combined with mutagenesis analysis, reveal a conserved recognition pattern of anaphylatoxins to the complement receptors that is different from chemokine receptors, unique pocket...

C3AR1 is an orphan G protein-coupled receptor for C3a, which is decomposed by C3. C3 and C3AR1 are closely related and play important roles in many BPs, such as the C3-C3a-C3AR1 pathway and the formation of intestinal organoids .

2023年7月20日 · In this study, we aim to characterize C3aR1 coupling preferences and investigate ligand-mediated C3aR1 signaling bias using endogenous agonists and other available C3aR1 ligands including the purported C3aR1 antagonist SB290157.

2025年2月8日 · Title: Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis. The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.

2021年8月16日 · We found that the complements C3, C5, C3AR1, and C5AR1 have deregulated expression in human malignancies and are associated with activation of immune-related oncogenic processes and poor prognosis of cancer patients.