A novel phosphocholine‐mimetic inhibits a pro‐inflammatory ...
Our finding that C10M reduces pCRP*/mCRP‐induced NETosis further highlights the relevance of CRP regulation as an important immune checkpoint and the therapeutic potential of C10M. …
Targeting conformational changes in C‐reactive protein to inhibit …
2022年12月5日 · The monovalent CRP inhibitor C10M prevents binding of pCRP to PC/PE and conformational change in pCRP toward pCRP*/mCRP and consequently reduces …
A novel phosphocholine-mimetic inhibits a pro-inflammatory ...
2023年1月11日 · C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism …
Discovery, in-vitro and in-vivo efficacy of an anti-inflammatory …
We designed a low molecular weight pCRP – PC inhibitor, C10M. Binding assays and X-ray crystallography revealed direct, competitive binding of C10M to pCRP, blocking interaction …
Pharmacokinetic study of the novel phosphocholine derivative 3 ...
2021年12月1日 · In this study, the pharmacokinetics and metabolism of the new drug candidate C10m was investigated. A sensitive and selective method for detection of C10m and its …
mCRP-Induced Focal Adhesion Kinase-Dependent Monocyte …
2024年3月7日 · Inclusion of a specific CRP dissociation/mCRP inhibitor (C10M) effectively inhibited PBMs clustering, as well as abrogating p-FAK expression, and partially reduced the …
Targeting conformational changes in C-reactive protein to inhibit …
2022年12月5日 · The monovalent CRP inhibitor C10M prevents binding of pCRP to PC/PE and conformational change in pCRP toward pCRP*/mCRP and consequently reduces pro …
Discovery, in-vitro and in-vivo efficacy of an anti-inflammatory …
2021年9月28日 · We designed a low molecular weight pCRP – PC inhibitor, C10M. Binding assays and X-ray crystallography revealed direct, competitive binding of C10M to pCRP, …
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory ...
2022年12月5日 · We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert, pentameric CRP (pCRP) structure to a pentameric …
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory ...
2022年12月5日 · Our finding that C10M reduces pCRP*/mCRP‐induced NETosis further highlights the relevance of CRP regulation as an important immune checkpoint and the …
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