C-Fos is an immediate early gene that plays a significant role in memory formation, as indicated by research findings in neuroscience. AI generated definition based on: Learning and Memory: A Comprehensive Reference, 2008

The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron’s activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels. For the ...

Adult c-fos −/− mice present a ∼40–60% reduction in their body weight and their brain size is significantly smaller as compared to c-fos +/+ mice. We have shown that this correlates with a decreased brain cell number.

The c-fos gene and the c-Fos protein are markers of cellular activity (for both neurons and glia) and easily expressed after a wide range of stimuli (both harmful and non-harmful), which makes them useful in various animal models and when used in conjunction with other labeling techniques. Currently, c-Fos immunohistochemistry is still widely ...

The c-fos gene is induced by a broad range of stimuli, and has been commonly used as a reliable marker for neural activity. Its induction mechanism and available reporter mouse lines are exclusively based on the c-fos promoter activity. Here, we ...

Mar 4, 2002 · Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival.

The presence of Fos, the protein product of the immediate-early gene c-fos, in a neuron has become a popular means to identify neurons that participate in a given function without losing the ability to know precisely where these neurons are.

The c-Fos proteins form heterodimers with Jun family proteins, and the resulting AP-1 complexes regulate transcription by binding to the AP-1 sequence found in many cellular genes. Emerging evidence suggests that c-fos is essential in regulating neuronal cell survival versus death.

Sep 1, 2014 · c-Fos expression is rapidly up-regulated after addition of NGF to cultured PC12 cells which induces neuritogenesis. If together with NGF, cells are fed a Nuclear Localization Signal Peptide (NLSP) that blocks the import of AP-1 transcription factors into the nucleus, neuritogenesis is abrogated despite the fact that c-Fos is expressed normally.

Nov 7, 2022 · c-Fos is a 380 amino acid protein with a basic leucine zipper region for dimerisation and DNA-binding and a transactivation domain at C-terminus, and, like Jun proteins, it can form homodimers. In vitro studies have shown that Jun–Fos heterodimers are more stable and have stronger DNA-binding activity than Jun–Jun homodimers.