2024年12月26日 · c-Fos，作为一种即早基因（immediate early gene, IEG）的表达产物，近年来在神经科学研究领域受到了广泛关注。 它不仅是神经元活性的重要标记物，还参与了记忆形成、学习、恐惧反应等多种脑功能的调控。

Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. [5] It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982).

是一种活性依赖基因c-fos的启动子，可作为兴奋神经元特异性启动子。 如图8所示，是发表在《Nature》杂志上题为“Optogenetic stimulation of a hippocampal engram activates fear memory recall”的文章，使用AAV9-TRE-ChR2-EYFP病毒注射c-fos-tTA小鼠，来监控ChR2–EYFP在小鼠海马DG区表达 ...

c-Fos (FOS)靶点介绍助您了解其蛋白功能，蛋白定位，蛋白表达，蛋白表达及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

Expression of c-Fos has been used to determine the neuronal circuits underlying the neuroendocrine, autonomical, and behavioral responses induced by stress. c-Fos mapping indicates that acute stress challenges activate the HPA axis, specifically the CRF-containing parvocellular neurons of the hypothalamus.

The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron’s activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels.

利用c-fos和Arc两种即早基因驱动的报告基因小鼠和病毒，更精确地实时特异性标记相关的神经元和神经环路，并选择性进行干预是神经科学研究的重要手段。

c-Fos基因属于 IEG （immediate early gene）的一类，是原癌基因的一种。 c-Fos最早被注意到是因为其在注射谷氨酸或去甲肾上腺素，甚至生理盐水后会在脑内累积。

Currently, c-Fos immunohistochemistry is still widely used, allowing active cells to be identified through a representative black nuclear label and then quantified. The methodology is relatively simple and standardized compared to other current techniques; however, many researchers have questioned its use due to its limitations.

2002年3月4日 · Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival.