BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。- 高纯度，全球文献引用。

BzATP: 一种P2X7 receptor agonists药物，由UCL Institute of Ophthalmology (UCL Institute of Ophthalmology)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: P2X7 receptor agonists(P2X purinoceptor 7 agonists)，治疗领域: 神经系统疾病，在研适应症: 神经退行性疾病，在研机构: UCL ...

BzATP triethylammonium salt is potent at P2X7 receptors with EC 50 s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively. For research use only. We do not sell to patients.

BzATP | C24H24N5O15P3 | CID 115205 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity.

2025年2月8日 · BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。 靶点

2022年7月23日 · Using calcium imaging in intact mice to survey a large number of DRG neurons and SGCs, we examined how intra-ganglionic purinergic signaling initiated by BzATP affects neuronal activities in vivo. We developed GFAP -GCaMP6s and Pirt -GCaMP6s mice to express the genetically encoded calcium indicator GGCaM6s in SGCs and DRG neurons, respectively.

2022年2月6日 · BzATP not only significantly increased the expression levels of CHOP, GADD34, ATF6, and HERP but also significantly decreases the XBP1 expression level in M1 macrophages. The present study showed that BzATP induces cellular stress in M1 macrophages by elevating the expression levels of UPR genes including CHOP, GADD34, ATF6, and reducing cell ...

BzATP triethylammonium salt作为P2X受体激动剂，对P2X1, P2X2, P2X3, P2X2/3, P2X4和P2X7的pEC50分别是8.74、5.26、7.10、7.50、6.19、6.31和5.33，对大鼠P2X7受体和小鼠P2X7的EC50分别是3.6 μM和285 μM。