BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. This particular family member plays an important role in the onset of endochondral bone formation in humans.

bmp-4 在钙化的动脉粥样硬化斑块中差异表达，是动脉粥样硬化血管钙化与正常骨形成机制之间的连接点。 BMP-4 通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。

BMP2和BMP4已被证明能够诱导多能干细胞进入脂肪细胞，主要通过Smad途径而不是非标准途径介导。 小鼠研究通常认为，BMP4诱导干细胞沿着白色脂肪细胞谱系分化，而BMP7诱导棕色脂肪细胞分化。

2025年3月30日 · BMP4 (Bone Morphogenetic Protein 4) is a Protein Coding gene. Diseases associated with BMP4 include Microphthalmia, Syndromic 6 and Orofacial Cleft 11. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

骨形态发生蛋白 (bone morphogenetic protein，BMP)又称骨 形成蛋白，是一组具有类似结构的高度保守的 功能蛋白，属于TGF-β家族。 BMP能刺激 DNA 的合成和细胞的复制，从而促进 间充质细胞 定向分化为 成骨细胞。 BMP是控制牙齿发育的重要分子。 [2] BMP (bone morphogenetic protein)称骨形态发生蛋白，它还是体内诱导骨和软骨形成的主要因子，并在肢体生长、 软骨内骨化 、 骨折 早期、软骨修复时表达，对骨骼的 胚胎发育 和 再生修复 起重要作用。 如今BMP …

骨形态发生蛋白 4 (BMP-4) 是一种多效性配体蛋白，属于 TGFβ 家族，参与血管系统循环，可以激活血管细胞上的受体。 BMP-4 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。 重组人 BMP-4 蛋白全长 116 个氨基酸 (S293-R408)，由 E. coli 大肠杆菌表达，不带标签。 * Please select Quantity before adding items. • Cell Rep. 2022 Dec 27;41 (13):111891. [Abstract]

2023年4月4日 · Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the formation of skeletal myotubes and vessels.

2025年2月8日 · BMP-4 is a negative regulator of VEGF-D-driven metastasis that induces vascular remodeling in lymph nodes. BMP4 loss-of-function mutations is associated with developmental eye disorders including SHORT syndrome.

BMP-4, a stimulator of chondrogenesis, both in vitro and in vivo, is a potential therapeutic agent for cartilage regeneration. Product Properties. E.coli-derived human BMP-4 protein, Ser293-Arg408, E399D. The recombinant Human BMP4 predicts a molecular mass of 13.25 kDa.

Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the for …