Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which primordial follicles develop into pre-ovulatory follicles.

2025年3月30日 · BMP15 (Bone Morphogenetic Protein 15) is a Protein Coding gene. Diseases associated with BMP15 include Ovarian Dysgenesis 2 and 46 Xx Gonadal Dysgenesis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

骨形态发生蛋白 -15 (bonemorphogenetic protein-15， BMP-15) 是近年来备受关注的卵母细胞源性生长因子之一。 Hosoe等报道BMP-15在牛的卵母细胞和卵丘细胞中均有表达， 且在母牛卵丘细胞中的表达水平显著高于小牛。 在小鼠卵巢中， BMP-15最早出现于初级卵泡中， 持续表达于卵泡晚期， 并维持至排卵后12hrs。 在不同年龄妇女的卵巢中， 均可检测到BMP-15的表达， 特别是在原始卵泡期， 但性腺外组织中尚未见。 在卵泡发育过程中， BMP-15在前期呈低水平表达， …

骨形态发生蛋白 15 (bmp-15;gdf9b) 又称生长分化因子 9b (gdf9b)，是 tgfβ 家族的一种多效配体蛋白，仅在卵泡细胞中表达。 BMP15 与 GDF9 密切相关，协同调控卵泡的遗传发育。

2005年4月29日 · The oocyte factor, bone morphogenetic protein-15 (BMP-15) has proven to be critical for normal fertility in female mammals. The biological functions of recombinant BMP-15 demonstrate its capacity to promote granulosa cell processes involved in early follicle growth, while simultaneously acting to restrict follicle-stimulating hormone (FSH ...

gdf-9、bmp-15是近年发现的对卵泡发育及卵巢功能有重要调控作用的卵巢局部旁分泌自分泌因子。近年研究显示多囊卵巢综合征及卵巢早衰患者gdf-9、bmp-15基因存在突变位点，提示我们gdf-9和bmp-15基因的异常将会干扰女性卵泡发育和卵巢功能。

Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis. These findings support the concept that an adequate amount of BMP15 secreted in the follicular fluid is critical for female fertility.

2024年11月2日 · Title: Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cells derived from human follicular fluid to oocyte-like cell. Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency.

骨形态发生蛋白 15： 该基因编码 tgf-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。

Bone Morphogenetic Protein-15 (BMP15) is an oocyte-derived growth factor belonging to the Transforming Growth Factor-beta (TGF-β) superfamily which is involved in follicular development as critical regulator of many granulosa cell processes [48–52].