Growth Differentiation Factor-5 (GDF-5; also called BMP-14 and CDMP-1) is a member of the BMP family of TGF-beta superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family.

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2011年11月6日 · BMP-14 is an important mediator for the growth and morphogenesis of various tissues and organs in mammals. The action of BMP-14 is more specially targeted to skeletal development. In vitro studies also show that the BMP-14 is expressed in early cartilage condensation, the perichondrium and the joint interzone [4, 5].

The present study investigated the effects of bone morphogenetic protein (BMP) 14 on BMSC differentiation in vitro. It was revealed that BMP14 significantly increased the expression of tendon markers (scleraxis and tenomodulin) at the mRNA and protein level, which led to the upregulation of sirtuin 1 (Sirt1) expression.

Sterile Filtered White lyophilized (freeze-dried) powder. Lyophilized from a 0.2μm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA. Less than 0.1EU/μg of rMuGDF-5/BMP-14 as determined by LAL method. We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.

Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide.Mature human GDF-5 ...

Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide.

Growth Differentiation Factor-5 (GDF-5; also called BMP-14 and CDMP-1) is a member of the BMP family of TGF-beta superfamily proteins. Mature mouse GDF-5 shares 99% aa sequence identity with both mature human and rat GDF-5.

BMP-14 (bone morphogenetic protein 14) is involved in enhancing proliferations of osteoblasts, periosteum cells and connective tissue fibroblasts. It also promotes endochondral bone growth, proper development of limb skeletons and joints, and odontogenesis. It interacts with BMP type II receptor (BMPR-II) and might be involved in bone ...

Growth Differentiation Factor-5, also known as BMP-14 and CDMP-1, is a member of the BMP family of TGF-beta superfamily proteins. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 ( BMPR-IB ) and a type II ( BMPR-II or Activin RII) serine/threonine kinase receptor which results in the phosphorylation and ...