Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family. [6] GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and ...

骨形态发生蛋白 11 (bmp-11; gdf11)，又称生长/分化因子 11，是一种多效配体蛋白，属于 tgfβ 家族。gdf-11/bmp-11 信号通过激活素受体 i 型、ii 型，导致 smad2 和 smad3 磷酸化，激发信号。gdf-11/bmp-11 是中枢神经系统 (cns) 形成和命运的重要调节因子。

2023年6月1日 · Growth differentiation factor 11 (GDF11), also known BMP-11 (Bone morphogenic protein 11), was discovered in 1999 by Nakhashima et al. [7], who described GDF11 as a novel member of BMP/TGF-β family that is a key factor in embryogenesis [7].

Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes. Since its discovery in 1999, studies have shown the involvement of ...

1975年11月12日 · BMP-11/GDF-11 and Myostatin/GDF-8 are both members of the TGF-beta superfamily that can activate SMAD2/3 phosphorylation via the type I receptors ALK4, ALK5, or ALK7. We tested the ability of BMP-11 and Myostatin to promote self-renewal of human embryonic stem cells (hESC) under feeder-free and seru …

BACKGROUND Growth differentiation factor 11 (GDF-11), also known as bone morphogenic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling.

GDF-11/BMP-11 蛋白是一种分泌信号蛋白，在发育过程中全局调节前/后轴模式，并在中胚层和神经组织模式中发挥关键作用。 GDF-11/BMP-11 对于椎骨和口面部发育至关重要，并通过 2 型激活素受体（ACVR2A 和 ACVR2B）和 1 型激活素受体（ACVR1B、ACVR1C 和 TGFBR1）发出信号，导致 SMAD2 和 SMAD3 磷酸化。 GDF-11/BMP-11 蛋白, Human (HEK293, solution) 是重组的 GDF-11/BMP-11 蛋白，由 HEK293 表达，不带标签。 GDF-11/BMP-11 蛋白, Human …

Bone morphogenetic protein-11 (BMP11), also known as growth differentiation factor-11 (GDF11), is implicated in skeletal development and joint morphogenesis in mammals. However, its functions in adipogenesis and energy homeostasis are mostly unknown. The present study investigates crucial roles of B …

2018年2月20日 · GDF11 (growth differentiation factor 11), also known as BMP (bone morphogenetic protein) 11, is a member of the BMP/TGF-β superfamily 15 and not only contributes to embryonic development and histogenesis but also plays a role in metabolic disorders, cancers, and heart- and skeletal-muscle rejuvenation in …

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11, a member of the transforming growth factor-β superfamily, has been reported to be involved in colorectal cancer. However, the roles of GDF11 in Chinese patients with liver cancer and the underlying mechanisms have …