A Modular Synthesis of the Bis-Tetrahydrofuran Core of …
2000年11月17日 · A pivotal reaction in this sequence is the iodoetherification reaction of the bis-pyranoside-alkene to a highly functionalized cis-2,5-disubstituted THF. In principle, assembly …
Stereoselective Chemoenzymatic Cascade Synthesis of the bis -THF …
2018年11月21日 · The synthesis of bis-THF-bis-epoxide 4 could be achieved in six steps from bis-acetate diol (R,R)-8 (Scheme 6a), starting with the protection of the vic-diol as the …
Synthesis of 10 stereochemically distinct bis-tetrahydrofuran ...
2009年11月18日 · Asimicin-type adjacent bis-tetrahydrofuran (bis-THF) acetogenins, such as asimicin, bullatacin, and trilobacin, are highly potent cytotoxic molecules. 1 Arguably, …
Synthesis of, and Structural Assignments to the Stereoisomers of Bis …
Construction of the polytetrahydrofuranyl building blocks 6−10 from the common bissiloxyacetone precursor 11 is detailed. The approach is concise and, for the bis-(THF) pair, capitalizes on the …
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors ...
The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C 2-symmetric dipeptide isostere are …
Highly diastereo- and enantioselective catalytic synthesis of the bis ...
2008年9月8日 · An efficient highly diastereo- and enantioselective synthesis of the bis-tetrahydrofuran (bis-THF) alcohol of several HIV protease inhibitors, including Brecanavir and …
Bis‐Tetrahydrofuran: a Privileged Ligand for Darunavir and a New ...
2006年9月1日 · Two inhibitors that incorporate bis-THF as an effective high-affinity P 2 ligand for the HIV-1 protease substrate binding site maintain impressive potency against mutant strains …
Synthesis of the C19–C30 bis-THF fragment of iriomoteolide-13a
The C19–C30 bis-THF fragment of the proposed structure of iriomoteolide-13a has been synthesized. The ω-mesyloxy-substituted stereotetrad possessing three continuous hydroxy …
Synthesis of bis-tetrahydrofuran core of salzmanolin using
2012年7月12日 · The bis-THF core of salzmanolin was commenced from d-glucose as starting material. Stereoselective bis-THF ring has been established following intramolecular …
Design of substituted bis-Tetrahydrofuran (bis-THF)-derived …
2011年4月14日 · We investigated substituted bis-THF-derived HIV-1 protease inhibitors in order to enhance ligand-binding site interactions in the HIV-1 protease active site. In this context, we …