A bile duct is any of a number of long tube-like structures that carry bile, and is present in most vertebrates. The bile duct is separated into three main parts: the fundus (superior), the body (middle), and the neck (inferior).

2023年1月1日 · In the liver, hepatocytes and biliary epithelial cells (BECs; also called cholangiocytes) are the 2 major epithelial lineages and play distinct roles in (1) metabolism, protein synthesis, detoxification; and (2) bile transport and modification, respectively.

2019年7月10日 · Our atlas comprises all the main liver cell types defined by the expression of marker genes, including hepatocytes, EPCAM + bile duct cells (cholangiocytes), CLEC4G + liver sinusoidal...

Bile duct formation requires coordinated cell-cell interactions, resulting in the regulation of cell differentiation and morphogenesis. Multiple signaling molecules and transcription factors have been identified as important regulators of bile duct development.

Hepatocytes and cholangiocytes are two important cell types in the liver. The coordinated function of these cells is involved in the production and secretion of bile.

2011年2月1日 · The bile ducts are lined by cholangiocytes, a specialized epithelial cell type that has a dual origin. Intrahepatic cholangiocytes derive from the liver precursor cells, whereas extrahepatic cholangiocytes are generated directly from the endoderm.

The smaller bile ducts are lined by cuboidal cells. The larger bile ducts are lined by columnar cells and may include goblet cells. Bile duct epithelial cells have prominent Golgi complexes, numerous cytoplasmic vesicles, and short luminal microvilli.

In humans, the intrahepatic biliary epithelium has been divided based upon the size of the ducts: small bile ductules (<15 μm in diameter), interlobular ducts (15-100 μm in diameter), septal ducts (100-300 μm in diameter), area ducts (300-400 μm in diameter), segmental ducts (400-800 μm in diameter) and hepatic ducts (> 800 μm in diameter ...

The intrahepatic bile ducts consist of a complex branching morphology. Here, Roos et al. demonstrate that a branching tubular architecture can be induced in human adult intrahepatic cholangiocyte organoids. These BRCOs faithfully recapitulate aspects of in vivo branching organs and can be used to study bile duct development.

2019年3月8日 · Cholangiocytes are epithelial cells lining the intrahepatic and extrahepatic bile ducts; they are heterogeneous in size and function and contribute to bile composition and flow by solute...