Cystathionine beta-lyase is a tetramer composed of identical subunits, and is constructed as a dimer of dimers, each associated with one molecule of PLP bound to the catalytic site by a lysine residue.

The enzyme cysteine-S-conjugate β-lyase (EC 4.4.1.13) catalyzes the chemical reaction. This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming).

2025年1月1日 · Cystathionine β-lyase (CBL), commonly known as β-cystathionase, is a pivotal enzyme within the γ-family of pyridoxal 5′-phosphate (PLP)-dependent enzymes, extensively recognized for its role in catalyzing the cleavage of the Cβ-S …

胱硫醚β裂解酶 ( Cystathionine beta-lyase , CBL EC4.4.1.8) 属于裂解酶类，催化胱硫醚β位裂解，在脱去丙酮酸和NH3后，生成同型半胱氨酸。 该酶在酶循环方法学中，用于血液中同型半胱氨酸的检测。

Cysteine conjugate β-lyase (β-lyase) is a pyridoxal phosphate-dependent enzyme that is able to metabolize S-cysteine conjugates via both transamination and β-elimination. It has been shown to be identical to glutamine transaminase K, and catalyzes the transamination of hydrophobic amino acids such as phenylalanine ( Cooper et al. 2008 ...

2013年4月1日 · The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.

胱硫醚β-合酶 (CBS) 是转硫途径的关键酶，负责将同型半胱氨酸转移到半胱氨酸的生物合成和硫化氢 (H 2 S) 的产生。 CBS 异常上调和 H 2过量产生 S有助于包括癌症和唐氏综合症在内的几种疾病的病理生理学。 因此，药理学 CBS 抑制已成为一种前瞻性的治疗方法。 在这里，我们描述了最常用的 CBS 抑制剂氨基氧乙酸 (AOAA) 的结合和抑制机制。 我们发现 AOAA 与 CBS 的结合比其各自的底物更紧密，并形成具有肟键的死端 PLP 结合中间体。 令人惊讶的是，丝氨酸而非半胱 …

Cysteine S-conjugate beta-lyases are pyridoxal 5'-phosphate-containing enzymes that catalyze beta-elimination reactions with cysteine S-conjugates that possess an electron-withdrawing group attached at the sulfur. The end products of the beta-lyase …

Cysteine S -conjugate β-lyases are pyridoxal 5′-phosphate (PLP)-containing enzymes that catalyze the conversion of cysteine S -conjugates [RSCH 2 CH (NH 3+)CO 2−] and selenium Se -conjugates [RSeCH 2 CH (NH 3+)CO 2−] that contain a leaving group in the β position to pyruvate, ammonium and a sulfur-containing fragment (RSH) or selenium-containing...

2019年4月19日 · Here, we report the identification of CBL, a gene required for embryo and root development in Arabidopsis, and encodes cystathionine beta-lyase (CBL), which catalyzes the penultimate step in methionine (Met) biosynthesis, and which also led to the discovery of a previous unknown, but crucial, metabolic contribution by the Met biosynthesis pathway.