Developmental Relationships of Four Exhausted CD8 + T Cell ... - PubMed
2020年5月19日 · Here, we defined a four-cell-stage developmental framework for Tex cells. Two TCF1 + progenitor subsets were identified, one tissue restricted and quiescent and one more …
四个耗尽的 CD8+ T 细胞亚群的发育关系揭示了潜在的转录和表观 …
CD8+ T 细胞耗竭是当前抗癌免疫疗法的主要障碍。 尽管如此，耗尽的 CD8+ T 细胞 (Tex) 的发育生物学仍然不明确，限制了旨在“重振”Tex 细胞的策略的改进。 在这里，我们为 Tex 细胞定义 …
Stat5 opposes the transcription factor Tox and rewires exhausted …
2023年12月12日 · We examined epigenetic transitions between Tex cell subsets and revealed a reciprocally antagonistic circuit between Stat5a and Tox. Stat5 directed Tex int cell formation …
Reversing CD8+ T cell exhaustion is a major challenge of cancer immunotherapy. Yet, the epigenetic stability of the exhaustion program remains a key hinderance. Beltra et al. identify …
Zeyu Chen - Google 学术搜索 - Google Scholar
MS Abdel-Hakeem, S Manne, JC Beltra, E Stelekati, Z Chen, K Nzingha, ... Nature immunology 22 (8), 1008-1019, 2021. 193: 2021: In vivo CD8+ T cell CRISPR screening reveals control by …
Beltra et al. define a hierarchical developmental pathway for CD8+ T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics underlying subset …
Developmental Relationships of Four Exhausted CD8 + T Cell …
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell …
Charting the Roadmap of T Cell Exhaustion - Cell Press
2020年5月19日 · In this issue of Immunity, Beltra et al. (2020) map out a differentiation trajectory of T cell exhaustion, delineating hierarchical developmental relationships and providing insight …
Developmental Relationships of Four Exhausted CD8 - PubMed …
Beltra et al. define a hierarchical developmental pathway for CD8 + T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics underlying subset …
Stat5 battles Tox for epigenetic control of T cell exhaustion
2023年12月20日 · Based on the enhanced accumulation and effector-NK-like features of STAT5CA cells, Beltra et al. evaluated their therapeutic potential in mice with established B16 …