Daniel Beltrá captures the profound beauty and vulnerability of the natural world in his photographs of natural landscapes and wildlife. Primarily a landscape photographer, Beltrá …

2020年5月19日 · Here, we defined a four-cell-stage developmental framework for Tex cells. Two TCF1 + progenitor subsets were identified, one tissue restricted and quiescent and one more …

2024年2月27日 · Prof. Dr. Beltra Jean-Christophe is an immunologist who studies the fundamental mechanisms regulating adaptive T-cell responses to pathogens and cancer. …

Temporal re-enforcement of Stat5 activity in TEX cells strongly synergized with PD-1 blockade at expanding TEXint cells and partially reprogrammed the epigenetic landscape of TEX cells to …

Beltra et al. define a hierarchical developmental pathway for CD8+ T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics underlying subset …

2020年5月11日 · Beltra et al. define a hierarchical developmental pathway for CD8+ T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics …

Reversing CD8+ T cell exhaustion is a major challenge of cancer immunotherapy. Yet, the epigenetic stability of the exhaustion program remains a key hinderance. Beltra et al. identify …

Taking advantage of the leading expertise of the Wherry Lab, and building on PICI’s collaborative network, Dr. Beltra is using cutting-edge immunology tools and computational approaches to …

CD8+ T 细胞耗竭是当前抗癌免疫疗法的主要障碍。 尽管如此，耗尽的 CD8+ T 细胞 (Tex) 的发育生物学仍然不明确，限制了旨在“重振”Tex 细胞的策略的改进。 在这里，我们为 Tex 细胞定义 …

2016年3月30日 · Spanish Photographer Daniel Beltrá’spassion for environmental conservation is evident in his stirring images of the natural world. “The unique perspective of aerial …