Temporal re-enforcement of Stat5 activity in TEX cells strongly synergized with PD-1 blockade at expanding TEXint cells and partially reprogrammed the epigenetic landscape of TEX cells to …

Daniel Beltrá captures the profound beauty and vulnerability of the natural world in his photographs of natural landscapes and wildlife. Primarily a landscape photographer, Beltrá …

2024年2月27日 · Prof. Dr. Beltra Jean-Christophe is an immunologist who studies the fundamental mechanisms regulating adaptive T-cell responses to pathogens and cancer. …

As a Parker Bridge Fellow, Dr. Beltra is currently developing a program to exploit TEX subsets biology to identify and characterize relevant pathways for the therapeutic manipulation of TEX …

2020年5月19日 · Here, we defined a four-cell-stage developmental framework for Tex cells. Two TCF1 + progenitor subsets were identified, one tissue restricted and quiescent and one more …

Using original murine models, I demonstrated a new role for the gamma-chain cytokines IL-2 and IL-15 in the development of CD8 T cell exhaustion (Beltra et al. PNAS 2016). This innovative …

Reversing CD8+ T cell exhaustion is a major challenge of cancer immunotherapy. Yet, the epigenetic stability of the exhaustion program remains a key hinderance. Beltra et al. identify …

2023年12月12日 · We examined epigenetic transitions between Tex cell subsets and revealed a reciprocally antagonistic circuit between Stat5a and Tox. Stat5 directed Tex int cell formation …

2023年12月12日 · We examined epigenetic transitions between Tex cell subsets and revealed a reciprocally antagonistic circuit between Stat5a and Tox. Stat5 directed Tex int cell formation …

D Costamagna, V Casters, M Beltrà, M Sampaolesi, A Van Campenhout, ... Cells 11 (21), 3351, 2022. 6: 2022: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia …