BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinositol (PtdIns), lipids essential for not only autophagy but other membrane trafficking processes.

Beclin-1 is a protein that in humans is encoded by the BECN1 gene. [5] [6] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. [7] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

2019年8月21日 · 加州大学的研究人员在新研究中揭示了一个调控细胞自噬的关键分子机制，他们发现一种称作ULK1的激酶通过磷酸化Beclin-1，激活脂酶VPS34，诱导了细胞自噬发生. 这篇文章中研究人员证实，当氨基酸缺乏或mTOR抑制时，激活的ULK1会磷酸化Beclin-1的Ser 14位点，由此提高VPS34复合体活性。 通过ULK导致Beclin-1 Ser 14位点磷酸化是哺乳动物充分诱导自噬的必要条件. beclin1有一个BH3结构域，bcl2等可以通过BH3结构域与beclin1结合而影响其活性。

2018年12月15日 · Beclin 1 是 Ⅲ 类 PI3K 复合物的亚基，Beclin 1 与自噬前体的结合启动自噬体的形成，因此该蛋白是自噬体形成所必须的。 而且，在哺乳动物中鉴定的第一个介导自噬的重要基因就是 Beclin 1 基因，它具有抗肿瘤和抗感染的功能。

Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. It interacts with several cofactors ...

2025年3月30日 · BECN1 (Beclin 1) is a Protein Coding gene. Diseases associated with BECN1 include Sphingolipidosis and Pancreatic Ductal Adenocarcinoma. Among its related pathways are Early SARS-CoV-2 Infection Events and Autophagy. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and phosphatidylinositol 3-kinase binding.

2025年3月3日 · Using conditional gene knockout mouse models, we demonstrated that loss of Beclin 1 (Becn1), a major regulator of mammalian autophagy, exclusively in the megakaryocytic lineage disrupted...

2015年4月1日 · Beclin 1是自噬关键调控蛋白之一，参与自噬体膜形成.近期，大量研究结果指出, Beclin 1是caspase家族蛋白酶的全新底物，可被caspase剪切.剪切后的Beclin 1失去自噬调节功能，转而加剧凋亡进程.因而，Beclin 1对细胞凋亡和自噬起着重要的调控作用.

Beclin-1, a vital regulatory protein, is necessary for initiating autophagy and impacts the fine balance between cell survival and death. The present review will comprehensively investigate how Beclin-1 controls autophagy in human cancers, assessing its effects on tumor advancement and drug resistance.

2021年6月17日 · BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinositol (PtdIns), lipids essential for not only autophagy but other membrane trafficking processes.