2019年5月15日 · Diffusion tensor imaging (DTI) is a form of magnetic resonance imaging (MRI) and is a powerful technique to study white matter microstructural integrity following BCAS. DTI is sensitized to the motion of water molecules as they interact within tissues and is used as a probe to infer brain anatomy.

2021年8月28日 · Chronic cerebral blood flow reduction and spatial working memory deficits were detected in the BCAS mice, along with significantly reduced mean fractional anisotropy (FA) values in the corpus callosum, external capsule, and hippocampus in MRI DTI analysis.

According to the DTI data, progressive microstructural deficits were present in both BCAS and BCAO rats. Minor alterations in the microstructural integrity were present in BCAS rats. Only small unilateral clusters in the frontoparietal somatosensory cortex and the external capsule/entorhinal cortex presented slightly attenuated mean diffusivity ...

2019年5月15日 · MRI analysis revealed a significant effect of BCAS on diffusion tensor imaging (DTI) parameters in white matter areas. After correction for multiple testing, significantly lower fractional anisotropy (FA) values were found in the corpus callosum and anterior commissure and significantly higher mean diffusivity values in the internal capsule.

2021年8月28日 · Results: Chronic cerebral blood flow reduction and spatial working memory deficits were detected in the BCAS mice, along with significantly reduced mean fractional anisotropy (FA) values in the corpus callosum, external capsule, and hippocampus in …

研究结果: (1)成功建立起BCAS血管性认知功能障碍小鼠模型,多普勒血流结果显示双侧颈总动脉狭窄2小时后白质区血流下降到正常水平的60-70%; (2)LFB染色证明BCAS组小鼠较对照组有明显的白质纤维脱髓鞘损伤,在胼胝体 (CC),内囊 (IC),新纹状体 (CPu)等白质区的差异具有统计学意义; (3)DTI相关参数分析显示,代表白质纤维完整性的部分各向异性 (FA)在BCAS组的视束 (OT),IC,CC等白质区有明显下降,代表脱髓鞘损伤的垂直扩散向量 (RD)在CC区有明显升高,而代表轴突损伤 …

2023年8月11日 · Bilateral carotid artery stenosis (BCAS) in rodents is a well-established model of VCID where most studies have focused on white matter pathology and subsequent cognitive deficit. Therefore, our aim was to study the implication of adult hippocampal neurogenesis in hypoperfusion-induced VCID in mice, and its relationship with cognitive ...

结果:DTI相关参数显示,代表白质纤维完整性的部分各向异性在模型组的视束、内囊、胼胝体等白质区明显下降 (P<0.05),代表脱髓鞘损伤的垂直扩散向量在胼胝体区明显升高 (P<0.05),代表轴突损伤的轴向扩散向量在各白质区均未见明显变化;LFB染色和电镜亦证明白质区有明显脱髓鞘损伤。 行为学试验证明模型组有明显的工作记忆错误 (P<0.001),无明显参考记忆错误,且工作记忆错误和DTI参数所示脑白质损伤之间明显相关 (P<0.05)。 结论:小鼠BCAS 30 d可以造成选择性白质损伤,并 …

目的：建立双侧颈总动脉狭窄（bcas）所致慢性低灌注脑白质损伤小鼠模型。 方法：C57BL/6J小鼠42只，随机分为假手术组和模型组各21只，建立慢性低灌注脑白质损伤模型，假手术组不造成狭窄，利用7T超高场显微磁共振、髓鞘染色和电镜技术检测白质区病变，利用 ...

Here, bilateral carotid artery stenosis (BCAS) is used to model ischemic WMI‐related cognitive impairment and uncover that optogenetic and chemogenetic activation of glutamatergic neurons in the medial prefrontal cortex (mPFC) promote the differentiation of oligodendrocyte precursor cells (OPCs) in the corpus callosum, leading to improvements ...