A BBSome is a protein complex that operates in primary cilia biogenesis, homeostasis, and intraflagellar transport (IFT). [1] The BBSome recognizes cargo proteins and signaling …

2020年1月17日 · The BBSome is a heterooctameric protein complex that plays a central role in primary cilia homeostasis. Its malfunction causes the severe ciliopathy Bardet-Biedl syndrome …

2009年6月23日 · The BBSome was discovered in 2007 by biochemical purification of BBS4-containing complexes from mammalian cells and is composed of seven highly conserved …

2021年9月15日 · BBSome纤毛內稳态循环包括以下5个步骤：1）BBSome从胞体招募进入基体；2）纤毛基部到顶部正向IFT运输；3）纤毛顶部重塑；4）纤毛顶部到基部反向IFT运输；以 …

Bardet-Biedl syndrome (BBS) is a rare, pleiotropic inherited autosomal recessive disorder characterized by retinal dystrophy, obesity, polydactyly, structural and functional renal …

2023年7月19日 · Here, we review the current literature on the structural assembly, transport regulation, and molecular functions of the BBSome, emphasizing its roles in cilium-related …

Bardet-Biedl syndrome (BBS) is a syndromic ciliopathy that has obesity as a cardinal feature. BBS is caused by mutations in BBS genes. BBS proteins control primary cilia function, and BBS …

In other cell types than PRs, the BBSome was shown to be required for removal of activated GPCRs from the ciliary membrane upon signaling pathway activation (Ye et al., 2018). Since …

1 天前 · ift 列车亚复合物在纤毛基部具有不同的定位模式：研究人员通过对 bbsome、ift - a 和 ift - b 亚复合物的成像观察，发现它们在纤毛基部的强度分布虽大致相似，但仍存在细微差异。ift - …

2009年6月23日 · What is the BBSome? The BBSome (pronounced bee-bee-zome) is a stable protein complex that functions in primary cilium biogenesis.