2025年3月28日 · BAX (BCL2 Associated X, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BAX include Colorectal Cancer and T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and …

2023年1月30日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl-2 researchers believe plays a critical role in regulating intrinsic apoptosis.[4]

Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

2023年1月30日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl-2 researchers believe plays a critical role in regulating intrinsic apoptosis.

2025年3月26日 · The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

2006年6月2日 · Bax (Bcl-2 Antagonist X) was identified by the Korsmeyer group as a Bcl-2-interacting protein that opposed Bcl-2 and promoted apoptotic cell death. 1 Bcl-X S (Bcl-X short) was identified by the...

参与激活参与细胞凋亡过程的半胱氨酸型内肽酶活性。作用于多个过程的上游或内部，包括动物器官发育；凋亡信号通路；和细胞凋亡过程的调节。位于胞质溶胶中；内质网；和线粒体外膜。 Bax 复合体的一部分。

1998年6月12日 · Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell death. The Bax protein shares highly conserved domains with Bcl-2, some of which are required for the formation of Bax–Bcl-2 heterodimers. Bax expression is elevated in certain tissues after apoptotic stimuli and can be directly regulated by p53.

2018年1月1日 · Bax as a critical proapoptotic member of Bcl-2 family proteins suppresses tumorigenesis and stimulates apoptosis. Interactions between Bcl-2 members control the fates of normal and cancer cells. Bax is not only the unique point for the intrinsic apoptotic pathway, but also participates in the extrinsic signaling.

该基因编码的蛋白质属于 BCL2 蛋白家族。 BCL2 家族成员形成异二聚体或同二聚体，并作为参与多种细胞活动的抗或促凋亡调节剂。 该蛋白与 BCL2 形成异二聚体，并起凋亡激活剂的作用。 Bax 与 BCL2 的关联和比率也决定了细胞在凋亡刺激后的存活或死亡。 据报道，该蛋白质与线粒体电压依赖性阴离子通道 (VDAC) 相互作用并增加其开放，从而导致膜电位损失和细胞色素 c 的释放。 该基因的表达受肿瘤抑制因子 P53 的调节，并已被证明参与 P53 介导的细胞凋亡。 已经报道了 …