2002年7月26日 · BAK1 is a serine/threonine protein kinase, and BRI1 and BAK1 interact in vitro and in vivo. Expression of a dominant-negative mutant allele of BAK1 causes a severe dwarf phenotype, resembling the phenotype of null bri1 alleles. These results indicate BAK1 is a component of BR signaling.

2025年3月28日 · BAK1 (BCL2 Antagonist/Killer 1) is a Protein Coding gene. Diseases associated with BAK1 include Absolute Glaucoma and Keratoacanthoma.Among its related pathways are Endometrial cancer and Intrinsic Pathway for Apoptosis.Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

BAK1 mRNA was not detectable in bak1-1, establishing that bak1-1 is a null allele . bak1-1 plants have a semidwarfed phenotype . The inflorescence length of bak1-1 is about 70% that of wild-type . Furthermore, bak1-1 plants produce a smaller rosette with rounded leaves and shortened petioles (Figures 4C and 4D).

Model of the BRI1/BAK1 receptor complex activation. The initial stages of BR-dependent activation of BRI1 and BAK1 are shown. BRI1 exists as a homodimer even in the absence of the ligand [].Upon binding of BRs autophosphorylation commences from BRI1, resulting in a basal level of signaling, even in the complete absence of BAK1 or its orthologs SERK1 and BKK1 …

The expression of BAK1 and BRI1 has been localized to the same region in plant tissues. Mutants lacking BAK1 (bak1-1 and bak1-2) exhibited compact rosette phenotypes and reduced sensitivity to BL. So far, seven different mutant alleles of BAK1 have been identified and used in various research studies . Fig. 1.

BAK1 is a pro-apoptotic Bcl-2 protein containing four Bcl-2 homology (BH) domains: BH1, BH2, BH3, and BH4. These domains are composed of nine α-helices, with a hydrophobic α-helix core surrounded by amphipathic helices and a transmembrane C-terminal α-helix anchored to the mitochondrial outer membrane (MOM). A hydrophobic groove formed along the C-terminal of …

2020年2月20日 · BAK1 (brassinosteroid-insensitive 1 (BRI1) associated receptor kinase 1) plays major roles in multiple signaling pathways as a coreceptor to regulate plant growth and development and stress response. However, the role of BAK1 in high light signaling is still poorly understood. Here we observed that …

2025年2月10日 · Furthermore, the aggie5/bak1-16 mutant exhibited seedling lethality when combined with the mutation of its closest homolog BKK1/SERK4. The data suggest that BAK1 kinase activity is required for its multiple functions in plant immunity, development, and cell death control. The isolation and characterization of these Aggie genes will contribute ...

2019年11月18日 · BAK1 directly interacts with and phosphorylates CNGC20 at specific sites in the C-terminal cytosolic domain, which in turn regulates CNGC20 stability. CNGC19, the closest homolog of CNGC20 with a low abundance compared with CNGC20, makes a quantitative genetic contribution to bak1/serk4 cell death only in the absence of CNGC20, supporting the ...

Therefore, BAK1 is involved in primary and secondary events under natural infection conditions. BAK1 and BKK1 negatively regulate autoimmune cell death. The proper balance of BAK1 and BKK1 and their associated partners is crucial in regulating cell death (Belkhadir et al. 2012; Halter et al. 2014; Dominguez-Ferreras et al. 2015; Imkampe et al ...