Bacterial Cell Wall Synthesis: New Insights from Localization …
Rod-shaped bacteria are considered to have two modes of cell wall synthesis: one associated with elongation and one associated with formation of the division septum, which, after division, becomes the “new pole” of both daughter cells (Fig. 1).
Peptidoglycan: Structure, Synthesis, and Regulation - EcoSal Plus
Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel antibiotic targets, and its role in infection.
Bacterial Cell Wall Synthesis: New Insights from Localization …
In this review, we integrate the knowledge on the last stages of PG synthesis obtained in previous studies with the new data available on localization of PG synthesis and PBPs, in both rod-shaped and coccoid cells.
Cell wall synthesis and remodelling dynamics determine ... - Nature
2022年9月12日 · The bacterial division apparatus catalyses the synthesis and remodelling of septal peptidoglycan (sPG) to build the cell wall layer that fortifies the daughter cell poles.
The architecture of the Gram-positive bacterial cell wall
2020年4月29日 · The primary structural component of the bacterial cell wall is peptidoglycan, which is essential for viability and the synthesis of which is the target for crucial antibiotics 1,2.
Coordination of bacterial cell wall and outer membrane ... - Nature
2023年3月1日 · Here we report the discovery of a regulatory interaction between the committed enzymes for the PG and LPS synthesis pathways in the Gram-negative pathogen Pseudomonas aeruginosa. We show that the...
Editorial: Bacterial Cell Wall Structure and Dynamics
2019年9月3日 · The last decade in particular has seen a resurgence in interest in the bacterial cell wall—a Pubmed search with the keywords “peptidoglycan synthesis bacteria” reveals a total of 7,762 publications, of which 3,532 (45%) were published in the last 10 years.
Imaging Bacterial Cell Wall Biosynthesis - PMC - PubMed …
Peptidoglycan is an essential component of the cell wall that protects bacteria from environmental stress. A carefully coordinated biosynthesis of peptidoglycan during cell elongation and division is required for cell viability.
Constructing and deconstructing the bacterial cell wall - PMC
The antibacterial antibiotics disproportionately target bacterial protein structure that is distinct from eukaryotic protein structure, notably within the ribosome and within the pathways for bacterial cell‐wall biosynthesis (for which there is not a eukaryotic counterpart).
Bacterial cell wall synthesis: new insights from localization ... - PubMed
In order to maintain shape and withstand intracellular pressure, most bacteria are surrounded by a cell wall that consists mainly of the cross-linked polymer peptidoglycan (PG).