Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. [5] [6] BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. [7] BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues. [8]

BRD4 是一种转录和表观遗传调节因子，在胚胎发生和癌症发展过程中起着关键作用。 作为溴结构域和末端外结构域 (BET) 家族的成员，BRD4 的特征在于具有两个串联溴结构域（BD1、BD2）。 BDs 结合靶蛋白（包括组蛋白）上的乙酰化赖氨酸残基，因而对具有多个乙酰化残基的蛋白质的亲和力更高。 BRD4与染色质上的超乙酰化组蛋白区域相互作用，在转录活性调控元件上积累并在起始和延伸步骤中促进基因转录。 BRD4与癌症. 神经母细胞瘤 （NB）是一种具有快速进展和高 …

Brd4抑制剂通过抑制Brd4与SEs结合，加速SEs与靶向启动子的信号转导，抑制肿瘤细胞癌基因的表达，促进肿瘤细胞死亡 。Brd4抑制剂一般分为两类：单价抑制剂和二价抑制剂。单价抑制剂能与BD1或BD2结合，二价抑制剂能同时与BD1和BD2结合。

2025年3月28日 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange Syndrome. Among its related pathways are Infectious disease and SARS-CoV-2 Infection. Gene Ontology (GO) annotations related to this gene include chromatin …

2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-spe …

2023年12月22日 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce cancer cell proliferation and...

2018年11月22日 · BRD4 is a transcriptional and epigenetic regulator that plays a pivotal role during embryogenesis and cancer development. As the other members of the Bromodomains and Extraterminal (BET) family (BRD2, BRD3 and the testis-ovary specific BRDT), BRD4 is characterized by two tandem bromodomains (BD1, BD2).

These data highlight the potential role of BRD4 in regulating signaling networks in both cancer cells and the surrounding tumor microenvironment and suggest that therapeutic targeting of BET proteins may represent a novel strategy to inhibit BRD4-mediated pathways in tumor cells and tumor-associated stroma that promote cancer progression.

2012年5月8日 · brd4 蛋白是溴结构域和超末端家族蛋白（bet）家族中最重要的功能蛋白，含两个溴结构域及一个超末端结构域。 brd4 的表达上调与肺癌、乳腺癌、急性髓系淋巴瘤、肝癌等多种肿瘤的发生发展密切相关。

2025年3月25日 · The BRD4 complex coordinate key regulatory steps in gene expression. We speculate on why SMARCA4 recruits BRD4 to cell stress and motility pathways. BRD4 is a pleiotropic protein most intensively studied as a regulator of transcriptional elongation, a highly regulated step in expression of intrinsic innate genes.