bpV(phen) | PTP/PTEN 抑制剂 | MCE - MCE-生物活性分子大师
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC 50 s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, …
BpV (HOpic) (Bisperoxovanadium) | PTEN 抑制剂 | MCE
BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC 50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.
PTEN inhibitors: An evaluation of current compounds
2015年1月1日 · Here we investigate the inhibition of PTEN by four available PTEN inhibitors, bpV (phen), bpV (pic), VO-OHpic and SF1670 and compared this inhibition with that of only 3 other …
PTEN inhibitor bpV (HOpic) confers protection against ionizing ...
2021年1月18日 · Phosphatase and Tensin Homolog on chromosome 10 (PTEN) antagonizes PI3K activity by dephosphorylating PIP3, thus suppressing PI3K/AKT signaling that could …
Pharmacological PTEN inhibition: potential clinical applications …
The data collected in this study indicated that PTEN inhibitors (bpV compounds and SF1670) improves the repair process and regeneration of eyes, lungs, muscle and nervous system. The …
PTEN inhibitor improves vascular remodeling and cardiac …
2020年11月19日 · BPV treatment significantly improved cardiac function, with reduced cardiomyocyte apoptosis, promoted angiogenesis, and activated PI3K/Akt/vascular endothelial …
PTEN Inhibition in Human Disease Therapy - PMC - PubMed …
PTEN inhibition by bpV(phen) is caused by the formation of Cys124-Cys71 oxidative disulfide-bridged PTEN species, which can be reverted by reducing agents, as it happens with the …
Mxene-bpV plays a neuroprotective role in cerebral ischemia
2024年7月29日 · Bisperoxovanadium (bpV), a derivative of vanadate, is a putative inhibitor of PTEN. Mxene-bpV, through PTEN inhibition and Akt activation, was more effective than …
bpV(phen) trihydrate | PTP/PTEN 抑制剂 | MCE - MCE-生物活性 ...
bpV(phen) trihydrate，一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂，对 PTEN，PTP-β 和 PTP-1B 的 IC50 为 38 nM，343 nM 和 920 nM。 bpV(phen) …
PTEN inhibitor bpV(HOpic) confers protection against ionizing
2021年1月18日 · Phosphatase and Tensin Homolog on chromosome 10 (PTEN) antagonizes PI3K activity by dephosphorylating PIP3, thus suppressing PI3K/AKT signaling that could …