2023年6月7日 · We developed a platform technology by genetically engineering the bovine papillomavirus L1 major capsid protein to insert a polyglutamic acid/cysteine motif in place of …

2017年3月14日 · Moreover, the absence of papillomavirus replication in vitro makes the use of recombinant protein a promising candidate for vaccine formulations. Hence, we developed an …

Recombinant L1 proteins can spontaneously self-assemble into a highly immunogenic structure that closely mimics the natural surface of native papillomavirus virions. This has served as the …

2017年3月14日 · In this preliminary study, we aimed to integrate data about BPV-1 L1 gene cloning and expression from a bacterial system (E. coli). Afterward, we characterized the L1 …

2012年6月21日 · Bovine papillomavirus type 1 (BPV-1) is an economically important virus that induces tumourigenic pathologies in horses and cows. Given that the BPV-1 L1 major coat …

1996年9月1日 · The papillomavirus major capsid protein L1 can assemble into capsids in vitro. To identify areas within the bovine papillomavirus type-1 L1 (BPV L1) protein that are important …

In several animal species and man, immunisation with papillomavirus-like particles (VLP) has been shown to protect efficiently from papillomaviral infection. Hypothesis: BPV-1 L1 VLPs …

2023年3月27日 · Here, we describe the production of BPV1 L1 as VLPs in a baculovirus expression vector system (BEVS) and the purification of these particles by Lentil Lectin …

2013年11月4日 · Here, we utilized a mucosal vaccine vector, bovine papillomavirus (BPV) virus-like particles (VLPs), as a platform to present HIV-1 neutralizing epitopes by inserting the …

Infection with bovine papillomavirus type 1 (BPV1) or BPV2 induces fibropapillomas in cows and skin sarcoids in horses. Prophylactic vaccination targeting BPV1 and BPV2 may reduce the …