2021年12月14日 · However, a "J"- or "U-shaped curve" in the association between diastolic BP and cardiovascular events has been observed in epidemiological studies, suggesting that both high diastolic BPs and diastolic BPs below a certain nadir are associated with higher risk of cardiovascular disease (CVD) events.

In this review, we summarize the evidence for a J-curve in the treatment of hypertension. Recent findings: The Systolic Blood Pressure Intervention Trial (SPRINT) reported that achieving a systolic BP target of 120 mmHg reduces cardiovascular disease in high-risk individuals, supporting more intensive BP reduction. However, contemporary ...

2012年11月15日 · Higher BP achieved during treatment (systolic BP ⩾ 140 mm Hg and diastolic BP ⩾ 90 mm Hg) were stronger risk factors for the incidence of both cerebrovascular and cardiac events and the risks...

However, a “J”- or “U-shaped curve” in the association between diastolic BP and cardiovascular events has been observed in epidemiological studies, suggesting that both high diastolic BPs and diastolic BPs below a certain nadir are associated with higher risk …

2021年12月1日 · Proponents argue that the low DBP is causative due to reduced coronary perfusion during diastole with obstructive coronary artery disease (CAD), whereas others postulate the J-curve represents reverse causality from underlying comorbidity.

The blood pressure (BP) J-curve debate started in 1979, and we still cannot definitively answer all the questions. However, available studies of antihypertensive treatment provide strong evidence for J-shaped relationships between both diastolic and ...

2013年11月18日 · Blood pressure (BP) is poorly controlled in the population, a phenomenon with adverse prognostic impact. 1 However, a more aggressive approach toward BP lowering has been tempered over the last 2 to 3 decades by some reports suggesting a paradoxical increase in morbidity and mortality associated with an excessive reduction in BP, the so-called ...

2012年10月4日 · According to the current state of knowledge, it seems reasonable to suggest lowering BP to values within the 130–139/80–85 mmHg range, possibly close to the lower values in this range, in all hypertensive patients and to be very careful with further BP level reductions, especially in high-risk hypertensive patients.

2013年11月18日 · Because an impaired cardiac function may reduce BP, reversed causality is probably the most likely explanation of the J-shaped relationship that exists between BP and mortality in treated heart failure patients, namely that there is a particularly marked reduction of survival in individuals in whom heart failure is associated with a low BP. 41 ...

2011年9月12日 · Over the years since it was first described by Stewart in 1979, 1 the J curve has been recognized to exist almost exclusively for the diastolic blood pressure level and mostly in patients with existing coronary artery disease. 2, 3 The exact location of where the critical diastolic J point has been reported to be progressively lower from Stewart...