BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein found in humans that is encoded by the BNIP3 gene. [5] BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival.

2025年3月30日 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Leiomyomatosis and Pancreatic Cancer. Among its related pathways are mTOR signaling pathway and Busulfan Pathway, Pharmacodynamics.

2022年4月11日 · Autophagy-mediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency, but the molecular mechanisms that link autophagy-mediated mitochondrial...

2009年2月20日 · BNIP3 (BCL2 and adenovirus E1B 19-kDa-interacting protein 3) and BNIP3-like (BNIP3L), also known as NIX, are proteins with homology to BCL2 in the BH3 domain, which induce both cell death and...

BNIP3 knockdown altered mitochondrial morphology, and number, and increased mitophagy. Interestingly, BNIP3 deficiency in NP cells reduced glycolytic capacity reflected by lower production of lactate/H + and lower ATP production rate.

2021年12月20日 · BNIP3L promotes mitophagy either via recruiting autophagosomes to target mitochondria or enhancing the formation of autophagosomes. BNIP3L-mediated mitophagy is regulated at the...

BNIP3 is a mitochondrial pro-apoptotic protein in the Bcl-2 superfamily, which is vital for the induction of tumour cell apoptosis, as well as the regulation of mitochondrial autophagy, apoptosis, and other functions in tumour cells.

2025年2月9日 · BNIP3 deletion can be used as a prognostic marker of tumor progression to metastasis in human triple-negative breast cancer; BNIP3 expression was found to be regulated by Sp3 in prostate cancer.

Recent studies have discovered that Bnip3 regulates mitochondrial dysfunction, mitochondrial fragmentation, mitophagy, cell apoptosis, and the development of lipid disorder diseases via numerous cellular signaling pathways.

2025年1月4日 · Title: Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome. BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.