2025年3月30日 · BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene. Diseases associated with BIRC5 include Adenocarcinoma and Malignant Pleural Mesothelioma. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Gene expression (Transcription).

BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients.

BIRC5 is a very promising and well-studied therapeutic target because of its preferential expression in tumor cells of adult individuals. Here we review some of the most relevant evidences about the role of BIRC5 emerged in hepatocellular carcinomas, gastrointestinal stromal tumors, prostate tumors and tumors of the nervous system.

An inhibitor of apoptosis (IAP) family member, baculoviral IAP repeat containing five (BIRC5) plays an important role in the occurrence and development of tumors. However, the underlying mechanism in human cancers remains unclear. In this study, we ...

2024年12月5日 · BIRC5 is a promising diagnostic and prognostic biomarker in multiple cancers. Its association with immune subtypes suggests a potential role in the tumor immune microenvironment. These findings support BIRC5 as a therapeutic target for cancer treatment.

2019年1月1日 · BIRC5, also known as survivin, has been implicated in cell cycle progression and apoptosis avoidance. BIRC5 is highly expressed in embryonic tissues, however very low or absent in adult tissues. BIRC5 overexpression has been frequently associated to cancer development, a poor prognosis and chemoresistance.

BIRC5 is an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers (Ambrosini et al., 1997). Progression of the cell cycle and control of apoptosis are thought to be intimately linked processes, acting to preserve homeostasis and developmental morphogenesis.

2023年11月19日 · BIRC5, a member of the apoptosis inhibitor (IAP) family, negatively regulates apoptosis or programmed cell death by inhibiting caspase activation. Due to these properties, overexpression of BIRC5 enables specific survival and division associated with …

2021年1月11日 · BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients.

2020年2月2日 · High BIRC5 expression was responsible for shorter relapse-free survival, worse overall survival, reduced distant metastasis free survival, and increased risk of metastatic relapse event. BIRC5–drug interaction network indicated that several common drugs could modulate BIRC5 expression.