The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane).

B细胞抗原受体(B-cell receptor, BCR)是一种位于B细胞表面的负责特异性识别及结合抗原的分子，其本质是一种膜表面免疫球蛋白(membrane immunoglobulin, mIg)。 BCR具有抗原结合特异性，每个个体的BCR多样性高达5x10^13，构成容量巨大的BCR库，赋予个体识别各种抗原、产生 ...

B 细胞抗原受体 (BCR) 由细胞膜免疫球蛋白 (mIg) 分子和相关的 Igα/Igβ (CD79a/CD79b) 异二聚体 (α/β) 组成。 mIg 亚单位结合抗原，导致受体聚集，同时 α/β 亚单位将信号转导至细胞内部。

2 天之前 · The B cell antigen receptor (BCR) is composed of membrane immunoglobulin (mIg) molecules and associated Igα/Igβ (CD79a/CD79b) heterodimers (α/β). The mIg subunits bind …

2022年9月15日 · B cell activation is triggered by antigen recognition by the B cell receptor (BCR), resulting in B cell proliferation and affinity maturation within germinal centers. 1 Notably, B cell...

2024年8月20日 · Positive selection of germinal center B cells depends on the affinity of their antigen receptors. Emerging evidence shows that optimal B cell receptor (BCR) signaling, as well as a balance between BCR and T cell help signals, is necessary for antibody affinity maturation in the generation of antibody diversity.

2018年1月19日 · The B cell receptor (BCR), a transmembrane receptor located on the cell surface of B lymphocytes, plays a key role in B cell development and adaptive immune responses,...

B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators.

6 天之前 · In addition to the dual BCR B cell subset, we can also study B/T biphenotypic cells using single-cell technology. The development of T and B cells is usually strictly distinguished, and they can be differentiated by markers such as CD19, CD20, CD3, TCR, and BCR. However, with ongoing exploration in immunology, some cells have been found to co ...

B cell receptor (BCR) is a kind of mIg, which is a characteristic molecule on the surface of B cells. BCR is composed of smlg and Igα/Igβ heterodimers, and smlg is responsible for specific recognition of antigens. Its variable regions are highly diverse and can recognize various epitopes. Igα/Igβ mainly plays the role of signal transduction.